Luke, then only 20, was to be Anthony's companion in his travels and in his preaching, tending to him in his last days and taking Anthony's place upon his death. He was appointed guardian of the Friars Minor in the city of Padua. In 1239 the city fell into the hands of its enemies. Nobles were put to death, the mayor and council were banished, the great university of Padua gradually closed and the church dedicated to St. Anthony was left unfinished. Luke himself was expelled from the city but secretly returned. At night he and the new guardian would visit the tomb of St. Anthony in the unfinished shrine to pray for his help. One night a voice came from the tomb assuring them that the city would soon be delivered from its evil tyrant.
After the fulfillment of the prophetic message, Luke was elected provincial minister and furthered the completion of the great basilica in honor of Anthony, his teacher. He founded many convents of the order and had, as Anthony, the gift of miracles. Upon his death he was laid to rest in the basilica that he had helped finish and has had a continual veneration up to the present time.