Katherine MacGregor played nasty gossip Harriet Oleson on the show.
After she died at 93 years old in 2018, Gilbert called her "outspoken and hilariously funny" in an Instagram post.
"A truly gifted actress as she was able to play a despicable character but with so much heart. Her Harriet Oleson was the woman our fans loved to hate. A perfect antagonist," she added.
"The thing people outside of our prairie family didn't know, was how loving and nurturing she was with the younger cast."
Before "Little House," MacGregor acted on shows like "Mister Peepers," "Mannix," "Emergency!" "All in the Family" and "Ironside."
She was also a successful Broadway actress and she returned to the theater after the show ended. She retired from acting in the early 2000s.