Fifth Disease

(Erythema Infectiosum; Parvovirus B19; Slapped Cheek Disease)


Fifth disease is a viral infection common in children. The infection results in a mild rash on the face, trunk, and limbs.
Fifth Disease
fifth disease
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Fifth disease is caused by a virus called parvovirus B19. About half of all adults have been infected with this virus at some time.The parvovirus is found in saliva, sputum coughed up from the lungs, and nasal mucus. It is usually spread from person to person through contact with those fluids.

Risk Factors

Fifth disease is more common in children.Contact with someone infected with parvovirus B19 may increase your chance of developing fifth disease.There is a parvovirus that can cause infections in cats and dogs. This is not the same virus that can make humans ill. Contact with an animal with a parvovirus will not make you ill.


The first signs of fifth disease usually occur within 4-14 days after becoming infected. These symptoms may include:
  • Low-grade fever
  • Headache
  • Stuffy or runny nose
A bright red rash on the face will begin to show a few days after these first signs. The rash is known as slapped cheek rash. Several days later, this rash spreads down the trunk and limbs. The rash usually goes away within 7-10 days.In some adults, there may be no symptoms or rash. Adults are more likely to have joint pain and swelling with this infection.


You will be asked about your symptoms and medical history. A physical exam will be done.Tests may include the following:
  • Examination of the rash
  • Blood test to identify antibodies to parvovirus


Talk with your doctor about the best treatment plan for you. Usually, fifth disease does not require any treatment other than rest.Treatment options include the following:


Antiviral medications can prevent or weaken infections caused by specific viruses. Right now, there are no antiviral medications for fifth disease.Some medications may help relieve some symptoms:
  • Acetaminophen or ibuprofen may help reduce joint pain or fever.
  • Anti-itch medications may be used to relieve itching caused by the rash.

People With Chronic Anemia

Fifth disease can cause more severe symptoms if you have sickle cell disease or other types of chronic anemia. You may develop a severe anemia. This is a dangerously low level of red blood cells. The anemia will require treatment. It may include hospitalization and blood transfusions.

People With Immune Problems

Weakened immune systems can lead to a more severe infection. If you have immune problems, special medical care may be advised. This may include preventive treatment with antibodies.

Women Who Are Pregnant

This type of infection can cause problems in about 5% of pregnant women. Although the complications are rare, they can be severe. A parvovirus B19 infection during pregnancy may cause a miscarriage or severe anemia in the baby. If you are pregnant and believe that you may have this infection or have been exposed to someone with the infection, see your doctor.

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