(Erythema Infectiosum; Parvovirus B19; Slapped Cheek Disease)
DefinitionFifth disease is a viral infection common in children. The infection results in a mild rash on the face, trunk, and limbs.
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CausesFifth disease is caused by a virus called parvovirus B19. About half of all adults have been infected with this virus at some time.The parvovirus is found in saliva, sputum coughed up from the lungs, and nasal mucus. It is usually spread from person-to-person through contact with those fluids.
Risk FactorsFifth disease is more common in children.Contact with someone infected with parvovirus B19 may increase your chance of developing fifth disease.There is a parvovirus that can cause infections in cats and dogs. This is not the same virus that can make humans ill. Contact with an animal with a parvovirus will not make you ill.
SymptomsThe first signs of fifth disease usually occur within 4 to 14 days after becoming infected. These symptoms may include:
- Low-grade fever
- Stuffy or runny nose
DiagnosisYou will be asked about your symptoms and medical history. A physical exam will be done.Tests may include the following:
- Examination of the rash
- Blood test to identify antibodies to parvovirus
TreatmentTalk with your doctor about the best treatment plan for you. Usually, fifth disease does not require any treatment other than rest.Treatment options include the following:
MedicationsAntiviral medications can prevent or weaken infections caused by specific viruses. Right now, there are no antiviral medications for fifth disease.Some medications may help relieve some symptoms:
- Acetaminophen or ibuprofen may help reduce joint pain or fever.
- Anti-itch medications may be used to relieve itching caused by the rash.
People With Chronic AnemiaFifth disease can cause more severe symptoms if you have sickle cell disease or other types of chronic anemia . You may develop a severe anemia. This is dangerously low level of red blood cells. The anemia will require treatment. It may include hospitalization and blood transfusions.
People With Immune ProblemsWeakened immune systems can lead to a more severe infection. If you have immune problems, special medical care may be advised. This may include preventive treatment with antibodies.
Women Who Are PregnantThis type of infection can cause problems in about 5% of pregnant women. Although the complications are rare they can be severe. A parvovirus B19 infection during pregnancy may cause a miscarriage or severe anemia in the baby. If you are pregnant and believe that you may have this infection or have been exposed to someone with the infection, see your doctor.
PreventionIt is difficult to prevent the spread of fifth disease. The virus is most easily passed on before the rash appears. People may not know they are infected.To help reduce your chances of getting any virus:
- Practice good hygiene.
- Wash your hands often.
- Try to avoid touching your eyes, mouth, and nose.
- Avoid close contact with people who are infected. Wash your hands after coming in contact with someone who has a virus.
Family Doctor—American Academy of Family Physicians
US Centers for Disease Control and Prevention
AboutKidsHealth—The Hospital for Sick Children
Fifth disease. Nemours Foundation website. Available at: http://kidshealth.org/parent/infections/bacterial%5Fviral/fifth.html. Updated January 2014. Accessed October 31, 2014.
Fifth disease. US Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/parvovirusB19/fifth-disease.html. Updated February 14, 2012. Accessed October 31, 2014.
Parvovirus B19 infection. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated October 27, 2014. Accessed October 31, 2014.
Pregnancy and fifth disease. US Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/parvovirusB19/pregnancy.html. Updated February 14, 2012. Accessed October 31, 2014.
- Reviewer: Kari Kassir, MD
- Review Date: 12/2014
- Update Date: 12/20/2014
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