DefinitionWhipple’s disease is a rare infectious disease. It is caused by a bacterium named Tropheryma whippleii .
CausesWhipple’s disease is caused by a specific type of bacteria. This bacterium causes abnormal changes on the wall of the small intestine. These changes disrupt the villi. Villi are tiny, finger-like structures that stick out from the wall of the intestine to help absorb nutrients. As a result, some nutrients are not absorbed properly and do not reach the rest of the body.
|Cross Section of Intestine With Villi|
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Risk FactorsThere is no evidence that Whipple’s disease is passed from person to person. But, there is some evidence that the bacteria may be present in people who are healthy. This suggests that the few people who develop the disease may have an abnormal response to the bacteria. Some people with Whipple’s disease may have a genetic defect that makes them more likely to develop the disease. Whipple’s disease occurs mainly in middle-aged men.
SymptomsThis disease can affect many parts of the body. The small intestine is the main organ affected. Symptoms usually begin slowly and occur in stages. The first stage includes:
- Pain in the joints (in 90% of cases)
- Pain and bloating in the abdomen
- Fatty foul-smelling stools
- Bleeding from the intestines
- Weight loss
- Fatigue (often from anemia )
- Cough and chest pain
- Increased skin pigmentation (in 50% of cases)
- Swollen lymph glands
DiagnosisThe doctor will ask about your symptoms and medical history. A physical exam will be done.
- Your doctor may need to test your bodily fluids, tissues, and waste products. This can be done with:
- Blood tests
- Stool tests
- Polymerase chain reaction (PCR) test
- Your doctor may need pictures of your bodily structures. This can be done with CT scan .
TreatmentTaking antibiotics can cure Whipple's disease. Often, a combination of antibiotics is used. These drugs kill the bacteria that cause the disease. Your doctor will work with you to find the best types and doses for you. Antibiotics may be given orally or by IV.If you have a more severe case of Whipple’s disease, you may also need intravenous antibiotics, fluid, and electrolyte replacement when you begin treatment. Electrolytes are salts and other substances in your body fluid that your heart and brain need to work properly. You may also need to take supplements of certain vitamins and minerals that your body is not absorbing normally on its own. These may include:
- Vitamins A, B12, D, E, and K
PreventionCurrently, there is no known way to prevent Whipple’s disease.
National Institute of Diabetes and Digestive and Kidney Diseases
National Organization for Rare Disorders
The Canadian Association of Gastroenterology (CAG)
Desnues B, Al Moussawi K, et al. New insights into Whipple's disease and Tropheryma whipplei infections. Microbes Infect . 2010;12(14-15):1102-1110.
Fenollar F, Nicoli F, et al. Progressive dementia associated with ataxia or obesity in patients with Tropheryma whipplei encephalitis. BMC Infect Dis . 2011;11:171.
Fenollar F, Trani M, et al.Prevalence of asymptomatic Tropheryma whipplei carriage among humans and nonhumanprimates. J Infect Dis . 2008;197(6):880-887.
Whipple disease. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us. Updated December 28, 2010. Accessed January 8, 2013.
Whipple's disease. National Digestive Diseases Information Clearinghouse website. Available at: http://digestive.niddk.nih.gov/ddiseases/pubs/whipple/index.aspx. Updated April 30, 2012. Accessed January 8, 2013.
Whipple’s disease: a rare, insidious disorder with serious consequences. Drug and Therapy Perspectives . 1999;13:8-10.
- Reviewer: Daus Mahnke, MD
- Review Date: 09/2013
- Update Date: 09/30/2013