Alternate Names :

  • Amethopterin
  • MTX

Trade Names :

  • Immunex
  • Folex PFS
  • Rheumatrex

Potassium Citrate - Possible Harmful Interaction St. John's Wort, Dong Quai - Possible Harmful Interaction White Willow - Possible Harmful Interaction Ipriflavone - Possible Harmful Interaction Citrate - Possible Harmful InteractionFolate - Supplementation Possibly Helpful

Methotrexate is used in cancer chemotherapy as well as for treating inflammatory diseases such as rheumatoid arthritis and psoriasis.

Potassium citrate and other forms of citrate (e.g., calcium citrate, magnesium citrate) may be used to prevent kidney stones. These agents work by making the urine less acidic. This effect on the urine may lead to decreased blood levels and therapeutic effects of methotrexate. 1It may be advisable to avoid these citrate compounds during methotrexate therapy except under medical supervision.

Dong QuaiSt. John's Wort St. John's wort (Hypericum perforatum) is primarily used to treat mild to moderate depression. The herb dong quai (Angelica sinensis) is often recommended for menstrual disorders such as dysmenorrhea, PMS, and irregular menstruation. Methotrexate has been reported to cause increased sensitivity to the sun, amplifying the risk of sunburn or skin rash. Because St. John's wort and dong quai may also cause this problem, taking these herbal supplements during methotrexate therapy might add to this risk.It may be a good idea to wear a sunscreen or protective clothing during sun exposure if you take one of these herbs while using methotrexate.

White Willow The herb white willow (Salix alba) , also known as willow bark, is used to treat pain and fever. White willow contains a substance that is converted by the body into a salicylate similar to aspirin. Case reports suggest that salicylates can increase methotrexate blood levels and toxicity. 2 For this reason, you should avoid combining white willow with methotrexate.

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