Potassium-Sparing Diuretics

Potassium —Likely Harmful Interaction Magnesium —Possible Harmful Interaction Arginine —Possible Harmful Interaction White Willow —Possible Negative Interaction Zinc —Possible Harmful Interaction

This family of diuretics was invented to avoid the potassium loss common with loop and thiazide diuretics.Potassium-sparing diuretics include drugs such as amiloride hydrochloride (Midamor), spironolactone (Aldactone), and triamterene (Dyrenium), among others.

PotassiumPotassium-sparing diuretics cause the kidneys to hold potassium in the body. When you are taking these medications you generally should not take potassium supplements because your potassium levels might rise too high.Treatments that combine thiazide diuretics (which cause potassium loss) and potassium-sparing diuretics can affect potassium levels unpredictably. If you are taking such a combination medication, do not take potassium except on the advice of your physician.

Magnesium Preliminary evidence from animal studies suggests that the potassium-sparing diuretic amiloride might cause the body to retain magnesium also, along with potassium. 2 Therefore, taking magnesium supplements might conceivably present the risk of excessive magnesium levels.

Arginine Based on experience with intravenous arginine, it is possible that the use of high-dose oral arginine might alter potassium levels in the body, especially in people with severe liver disease. 1 This is a potential concern for individuals who take potassium-sparing diuretics.

White WillowThe herb white willow contains substances very similar to aspirin. On this basis, it might not be advisable to combine white willow with potassium-sparing diuretics.

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