Arrhenoblastoma

(Androblastoma; Sertoli-Leydig Cell Tumor of the Ovary)

Definition

An arrhenoblastoma is a rare type of ovarian tumor. This tumor primarily secretes the male sex hormone, testosterone, and rarely the female sex hormone, estrogen.Arrhenoblastomas are generally benign, meaning they do not normally spread beyond the ovary.
Arrhenoblastoma
Ovarian Cancer
Copyright © Nucleus Medical Media, Inc.

Causes

The cause of arrhenoblastoma is unknown.

Risk Factors

Arrhenoblastomas are most common in young women between the ages of 20 and 30 years of age. However, they can occur at any age, including in toddlers, young girls, and postmenopausal women. Arrhenoblastoma mare also be a rare complication of pregnancy.

Symptoms

In many cases, infrequent menstrual periods or cessation of menstrual periods is the only symptom. In up to one in three patients, arrhenoblastoma is accompanied by masculinization, including any of the following:

Diagnosis

You will be asked about your symptoms and medical history. A physical exam will be done. Your bodily fluids may be tested. This can be done blood tests of hormone levels. Images may be taken of your bodily structures. This can be done with ultrasound.
Pelvic Ultrasound
Pelvic Ultrasound
Copyright © Nucleus Medical Media, Inc.

Treatment

Treatment involves surgery to remove one or both ovaries. This procedure is usually successful in returning normal menstruation (in premenopausal women) and ceasing masculinization. If the tumor is late stage and particularly aggressive (which is rare), radiation therapy , chemotherapy , or both, in addition to surgery, may be needed.

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Prevention

There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown.

RESOURCES

The Endocrine Society
http://www.endo-society.org

Ovarian Cancer National Alliance
http://www.ovariancancer.org

CANADIAN RESOURCES

Canadian Cancer Society
https://www.cancer.ca

Ovarian Cancer Canada
http://www.ovariancanada.org

References

Chen F, Sheu B, et al. Sertoli-leydig cell tumor of the ovary. J Formos Med Assoc. Available at: http://cat.inist.fr/?aModele=afficheN&cpsidt=17460145. Accessed October 29, 2014.

Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. J Clin Endocrinol Metab. 2002;87:49-56.

Colombo N, Parma G, et al. Management of ovarian stromal cell tumors. J Clin Oncol. 2007;20:2944-2951.

Leydig cell tumor. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated February 28, 2011. Accessed October 29, 2014.

McCluggage WG, McKenna M, et al. CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord stromal tumor. Int J Gyn Pathol. 2007;26:322-327.

Sachdeva P, Arora R, et al. Cell tumor: a rare ovarian neoplasm. Gynecologic Endocrinology. 2008;24(4):230-234.

Sex cord-stromal tumors. Johns Hopkins Pathology website. Available at: http://ovariancancer.jhmi.edu/stromal.cfm. Updated June 25, 2001. Accessed October 29, 2014.

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