Sublingual Immunotherapy

Alternate Name

  • SLIT


Principal Proposed Uses

Other Proposed Uses

  • Asthma
  • Latex Allergy
  • Other Forms of Allergy


Sublingual immunotherapy (SLIT) is a method of treating allergies that closely resembles conventional "allergy shots." In both of these methods, small amounts of allergenic substances are administered periodically and over a long period of time, via a route different from that in which the body ordinarily encounters them. For example, plant pollens ordinarily cause their allergic reactions by being inhaled. With allergy shots, pollen extracts are injected under the skin, while in SLIT, they are placed under the tongue. The immune system has many components, and only one of them, the IgE/eosinophil system, produces typical allergic reactions. The intended effect of these alternate routes of administration is to “train” other branches of the immune system to neutralize allergens before the IgE/eosinophil system even (so to speak) notices that they are there.The great potential advantage of SLIT over allergy shots is that SLIT does not involve needles; this makes it less unpleasant and also capable of being done at home rather than at a doctor’s office. The absence of needles may also explain why SLIT has long been categorized as a form of alternative rather than conventional medicine. There are no universally accepted criteria by which a treatment is classified as part of "alternative" rather than conventional medicine. Some treatments, such as acupuncture , fall in the alternative category because they belong to a system of medicine considerably unlike that of the modern conventional system; others, like traditional herbology, fall in the alternative category because they involve unprocessed "natural" substances rather than drugs; still others do so simply because they have been rejected for one reason or another by conventional medicine and/or have been adopted by practitioners of other forms of alternative medicine. Sublingual immunotherapy (SLIT) falls primarily in the last camp. Until approximately the year 2000, SLIT was most commonly the province of practitioners who identified themselves as holistic or alternative, and it was looked on with skepticism by mainstream medicine. In recent years, however, numerous well-designed studies of SLIT have been reported, causing the method to gain increasing acceptance among conventional allergists.

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