Harrison died at 1:30 p.m. (2130 GMT) Thursday at a friend's Los Angeles home following a battle with cancer, longtime friend Gavin De Becker told The Associated Press late Thursday. Harrison's wife, Olivia Harrison, and son Dhani, 24, were with him.
''He left this world as he lived in it, conscious of God, fearless of death, and at peace, surrounded by family and friends,'' the Harrison family said in a statement. ''He often said, 'Everything else can wait, but the search for God cannot wait, and love one another.'''
With Harrison's death, there remain two surviving Beatles: Paul McCartney and Ringo Starr. John Lennon was shot to death by a deranged fan in 1980.
''I am devastated and very, very sad,'' McCartney told The Press Association, a British news agency, early Friday. ''He was a lovely guy and a very brave man and had a wonderful sense of humor. He is really just my baby brother.''
It wasn't immediately known if there would be a public funeral for Harrison. A private ceremony had already taken place, De Becker said.
In 1998, Harrison disclosed that he had been treated for throat cancer. ''It reminds you that anything can happen,'' he said at the time. The following year, Harrison survived an attack by an intruder who stabbed him several times. In July 2001, he released a statement asking fans not to worry about reports that he was still battling cancer.
The Beatles were four distinct personalities joined as a singular force in the rebellious 1960s, influencing everything from hair styles to music. Whether dropping acid, proclaiming ''All You Need is Love'' or poking fun at the squares in the film ''A Hard Day's Night,'' the Beatles inspired millions.
Harrison's guitar work, modeled on Chuck Berry and Carl Perkins among others, was essential.
He often blended with the band's joyous sound, but also rocked out wildly on ''Long Tall Sally'' and turned slow and dreamy on ''Something.'' His jangly 12-string Rickenbacker, featured in ''A Hard Day's Night,'' was a major influence on the American band the Byrds.
Although his songwriting was overshadowed by the great Lennon-McCartney team, Harrison did contribute such classics as ''Here Comes the Sun'' and ''Something,'' which Frank Sinatra covered. Harrison also taught the young Lennon how to play the guitar.
''As he said himself, how do you compare with the genius of John and Paul? But he did, very well,'' rock star and activist Bob Geldof told BBC radio.
He was known as the ''quiet'' Beatle and his public image was summed up in the first song he wrote for them, ''Don't Bother Me,'' which appeared on the group's second album.
But Harrison also had a wry sense of humor that helped shape the Beatles' irreverent charm, memorably fitting in alongside Lennon's cutting wit and Starr's cartoonish appeal.
At their first recording session under George Martin, the producer reportedly asked the young musicians to tell him if they didn't like anything. Harrison's response: ''Well, first of all, I don't like your tie.'' Asked by a reporter what he called the Beatles' famous moptop hairstyle, he quipped, ''Arthur.''
He was even funny about his own mortality. As reports of his failing health proliferated, Harrison recorded a new song - ''Horse to the Water'' - and credited it to ''RIP Ltd. 2001.''
He always preferred being a musician to being a star, and he soon soured on Beatlemania - the screaming girls, the hair-tearing mobs, the wild chases from limos to gigs and back to limos. Like Lennon, his memories of the Beatles were often tempered by what he felt was lost in all the madness.
''There was never anything, in any of the Beatle experiences really, that good: even the best thrill soon got tiring,'' Harrison wrote in his 1979 book, ''I, Me, Mine.'' ''There was never any doubt. The Beatles were doomed. Your own space, man, it's so important. That's why we were doomed, because we didn't have any. We were like monkeys in a zoo.''
Still, in a 1992 interview with The Daily Telegraph, Harrison confided: ''We had the time of our lives: We laughed for years.''
''George has given so much to us in his lifetime and continues to do so even after his passing, with his music, his wit and his wisdom,'' Lennon's widow, Yoko Ono said Friday.
Alan Williams, The Beatles' first manager, described Harrison as the major cog in The Beatles. ''He kept them together probably because of the calming effect he had,'' Williams said.
After the Beatles broke up in 1970, Harrison had sporadic success. He organized the concert for Bangladesh in New York City, produced films which included Monty Python's ''Life of Brian,'' and teamed with old friends, including Bob Dylan and Roy Orbison, as ''The Traveling Wilburys.''
George Harrison was born Feb. 25, 1943, in Liverpool, one of four children of Harold and Louise Harrison. His father, a former ship's steward, became a bus conductor soon after his marriage.
Harrison was 13 when he bought his first guitar and befriended Paul McCartney at their school. McCartney introduced him to Lennon, who had founded a band called the Quarry Men - Harrison was allowed to play if one of the regulars didn't show up.
''When I joined, he didn't really know how to play the guitar; he had a little guitar with three strings on it that looked like a banjo,'' Harrison recalled of Lennon during testimony in a 1998 court case against the owner of a bootleg Beatles' recording.
''I put the six strings on and showed him all the chords - it was actually me who got him playing the guitar. He didn't object to that, being taught by someone who was the baby of the group. John and I had a very good relationship from very early on.''
Harrison evolved as both musician and songwriter. He became interested in the sitar while making the 1965 film ''Help!'' and introduced it to a generation of Western listeners on ''Norwegian Wood,'' a song by Lennon from the ''Rubber Soul'' album. He also began contributing more of his own material.
Among his compositions were ''I Need You'' for the soundtrack of ''Help''; ''If I Needed Someone'' on ''Rubber Soul''; ''Taxman'' and ''Love You To'' on ''Revolver''; ''Within You, Without You'' on ''Sgt. Pepper''; and ''While My Guitar Gently Weeps'' on the White Album.
In 1966, he married model Patti Boyd, who had a bit part in ''A Hard Day's Night.'' (They divorced in 1977, and she married Harrison's friend, the guitarist Eric Clapton, who wrote the anguished song ''Layla'' about her. Harrison attended the wedding.)
More than any of the Beatles, Harrison craved a little quiet. He found it in India. Late in 1966, after the Beatles had ceased touring, George and Patti went to India, where Harrison studied the sitar with Ravi Shankar. He maintained a lifelong affiliation with that part of the world.
In 1967, Harrison introduced the other Beatles to the teaching of the Maharishi Mahesh Yogi, and all four took up transcendental meditation. Harrison was the only one who remained a follower - the others dropped out, with Lennon mocking the Maharishi in the song ''Sexy Sadie.''
By the late '60s, Harrison was clearly worn out from being a Beatle and openly bickered with McCartney, arguing with him on camera during the filming of ''Let It Be.''
As the Beatles grew apart, Harrison collaborated with Clapton on the song ''Badge,'' performed with Lennon's Plastic Ono Band and produced his most acclaimed solo work, the triple album ''All Things Must Pass.'' The sheer volume of material on that 1970 release confirmed the feelings of Harrison fans that he was being stifled in the Beatles.
But one of those songs, the hit ''My Sweet Lord,'' later drew Harrison into a lawsuit: The copyright owner of ''He's So Fine,'' written by Lonnie Mack and recorded by The Chiffons, won a claim that Harrison had stolen the music.
Another Harrison project also led to legal problems. Moved by the starvation caused by the war between Bangladesh and Pakistan, Harrison in 1971 staged two benefit concerts at Madison Square Garden and recruited such performers as Starr, Shankar, Clapton and Dylan.
Anticipating such later superstar benefits as Live Aid and Farm Aid, the Bangladesh concerts were also a cautionary tale about counterculture bookkeeping. Although millions were raised and the three-record concert release won a Grammy for album of the year, allegations emerged over mishandling of funds and the money long stayed in escrow.
Despite the occasional hit single, including the Lennon tribute song ''All Those Years Ago,'' Harrison's solo career did not live up to initial expectations. Reviewing a greatest hits compilation, Village Voice critic Robert Christgau likened him to a ''borderline hitter they can pitch around after the sluggers (Lennon and McCartney) are traded away.''
Harrison's family life was steadier. He married Olivia Arias in 1978, a month after Dhani was born.
The next year, Harrison founded Handmade Films to produce Monty Python's ''Life of Brian.'' He sold the company for dlrs 8.5 million in 1994.
Fame continued to haunt him. In 1999, he was stabbed several times by a man who broke into his home west of London. The man, who thought the Beatles were witches and believed himself on a divine mission to kill Harrison, was acquitted on grounds of insanity.
But fame also continued to enrich Harrison. The following year, he saw a compilation of Beatles No. 1 singles, ''1,'' sell millions of copies and re-establish the band's status around the world.
''The thing that pleases me the most about it is that young people like it,'' he said in an interview with The Associated Press. ''It's given kids from 6 to 16 an alternate view of music to what's been available for the past 20 years.
''I think the popular music has gone truly weird,'' he said. ''It's either cutesy-wutesy or it's hard, nasty stuff. It's good that this has life again with the youth.''
John Chambers, of the Liverpool Beatles Appreciation Society, said Harrison's death was the end of an era for Beatles fans.
''Until now there has always been the hope of a reunion, perhaps with Julian Lennon standing in for his dad,'' Chambers said. ''It really is the end of a dream.''
At Harrison's mansion near London, fans left bunches of roses and lilies. One note read: ''The world will never be the same''; another said: ''The music, the rock 'n' roll life you led won't be forgotten.''
Fans in New York began gathering before dawn Friday at Strawberry Fields, a section of Central Park created in memory of Lennon, who was shot outside his apartment nearby.
''I just decided to buy a bottle of wine and some roses at the corner and head over here,'' said restaurateur John Soler, 38.
Added Pete Degan, 42: ''It's a sad day for rock and roll.''