McCain is learning the price he has to pay for being a maverick:

Employees from the securities, construction, pharmaceutical and energy industries, who accounted for about a tenth of Bush’s money in 2004, are turned off by his record and giving more to his Democratic rivals, Senators Hillary Clinton and Barack Obama.
“A significant percentage of your base Republican support, whether financial or otherwise, are not fans of McCain because of various things he’s done or said or sponsored,” said Republican consultant Eddie Mahe, who is supporting the Arizona senator. “Many of them don’t see Mr. McCain as being a lot better” than the Democrats.

Obama and Clinton each raised close to $11 million from the four industries through the end of March, compared with $6 million for McCain. In 2004, Bush raised three times more money from those sources than Senator John Kerry, the Democratic nominee that year.
[…]
“Our PAC supports members of Congress who are supportive of increased transportation investment,” ARTBA spokesman Matthew Jeanneret said. “I don’t think he fits that definition.”
McCain, 71, who voted against the 2005 legislation allocating $286.5 million for highways and transit, proposed suspending the 18.4-cent-per-gallon federal gas tax for the summer, eliminating the main source of revenue for federally funded road projects. Clinton also supports a gas-tax holiday.
[…]
“McCain has not characterized himself as a friend of the industry,” said Dan Mendelson, president of Avalere Health LLC, a Washington research company.
[…]
“How could pharmaceutical companies be able to cover up the cost to the point where nobody knows? Why shouldn’t we be able to re-import drugs from Canada?” McCain asked.
One of his opponents, former Massachusetts Governor Mitt Romney, interjected, telling McCain not to paint drug companies as “big bad guys.”
“Well, they are,” McCain responded.

(via)