Confusion with time or place. Occasionally, we might forget but then remember what day it is or when a particular activity will take place. Alzheimer’s disease can impact the part of the brain associated with orientation to time and place and make it consistently difficult, if not impossible, to remember things like appointments or dates. The person with Alzheimer’s might have an impaired sense of time and place, and make telephone calls at “odd” hours (very early morning, for example) or show up repeatedly at the wrong place for an appointment.