{"id":26035,"date":"2013-07-19T20:51:29","date_gmt":"2013-07-20T00:51:29","guid":{"rendered":"http:\/\/blog.beliefnet.com\/watchwomanonthewall\/?p=26035"},"modified":"2013-07-19T20:51:29","modified_gmt":"2013-07-20T00:51:29","slug":"new-genes-idd-in-obesity-how-much-of-weight-is-genetic","status":"publish","type":"post","link":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html","title":{"rendered":"New Genes IDd in Obesity: How Much of Weight is Genetic?"},"content":{"rendered":"
\"Drs.<\/a>
Drs. Michael and Mary Dan Eades – PROTEIN POWER – Website – www.eatprotein.com<\/a> –<\/figcaption><\/figure>\n

Calvin’s Commentary<\/b><\/span><\/span><\/span><\/strong>: The article below is most interesting concerning the topic, “Is obesity written in our genes?” Most assuredly, I believe it is.\u00a0 I have found that the best way for people I have met and interacted with in my lifetime – those who truly struggle with a weight issue – to lose weight – who have been battling it all their lives is to eat a low-carb diet<\/span>! I can personally attest to this – I’ve been fighting with my weight all my life<\/span>! I know hundreds of men and women who have been battling just as arduously as I have.\u00a0 I have belonged to several weight groups both online and those who meet face to face in groups.\u00a0 The vast majority of people who have success losing weight and keeping it off eat a low-carb diet, completely opposite of what Michelle Obama describes.\u00a0 I personally have found the most reasonable and best diet is what\u00a0Drs. Michael and Mary Dan Eades follow.\u00a0 It lowers blood pressure and cholesterol quickly!\u00a0 Type II Diabetes is assuaged — eliminated as long as one keeps following a low-carb diet without any form of medications.\u00a0 Dr. Eades and his wife, Mary, also a doctor, have followed this diet all their adult lives along with their children who are long ago grown up.\u00a0 They are all healthy.\u00a0 The best book they wrote is: PROTEIN POWER and can be borrowed “free” at any library – or for as little as 50\u00a2 on amazon.com (used paperback).\u00a0 I never suggest spending more money than you already have trying to fight the eternal battle of weight loss and keeping it off.\u00a0 I am not a medical doctor and I have no license to give anyone advice on their diet.\u00a0 I have NO interest or association with Dr. Eades or PROTEIN POWER.\u00a0 I will not benefit in any way if you do or do not get PROTEIN POWER or anything else from Dr. Eades.\u00a0 PROTEIN POWER website is www.eatprotein.com<\/a>.\u00a0 This is here simply FYI – because it is what worked for me – when I worked it.<\/em>\u00a0 Read the article below.\u00a0 I found it very informative. <\/span><\/span><\/span><\/strong>\u25ac <\/b><\/span><\/span><\/span><\/strong>Donna Calvin<\/span><\/span><\/span><\/a><\/strong> \u25ac Friday, July 19, 2013 <\/b><\/span><\/span><\/span><\/strong><\/p>\n

\"feet<\/a><\/p>\n

Two studies zero in on DNA-based drivers of weight. Is obesity written in our genes?<\/h1>\n

In two separate papers, published in the journal Science<\/em> and in the Journal of Clinical Investigation (JCI)<\/em>, researchers describe new genetic factors that could explain weight gain in some people. In the Science<\/em> study, researchers at Boston Children\u2019s Hospital studying mice found a rare genetic mutation that prevented the animals<\/a> from burning off fat calories. They also found the same gene was mutated in a group of obese people. And a team based at University College London reported in JCI<\/em> that a specific form of a gene previously linked to obesity, FTO, can increase craving for high-fat foods.<\/p>\n

The discoveries add to the growing body of knowledge about the biology behind weight, and the results confirm that while it\u2019s represented by a single number, weight is the complex combination of a multitude of different metabolic processes, from brain<\/a> systems that regulate appetite to enzymes that control how efficiently calories are turned from food into energy that the body needs. Making matters even more confusing, these factors are also likely influenced by environmental contributors such as diet and lifestyle.<\/p>\n

In the mouse study, the research team determined that mutations in the\u00a0Mrap2 gene led the animals to eat less initially but still gain about twice as much weight as they normally would. While their appetites returned, these mice continued to gain weight despite being fed the same number of calories as a group of control animals. That led the scientists to figure out that the mice with the mutated gene were simply sequestering fat rather than breaking it down for energy. The mice, like people, possessed two copies of the gene, and mice with even one defective copy experienced significant weight gain, although not as much as those who had two mutated versions of Mrap2.<\/p>\n

The scientists found a similar pattern among a group of 500 obese people; they detected four mutations in the human version of Mrap2, and each of the obese individuals possessed only one bad version of the gene.<\/p>\n

(MORE:<\/strong> Study Identifies Four New Genetic Markers For Severe Childhood Obesity<\/a>)<\/p>\n

In the British study, the researchers divided a group of 359 healthy men of normal weight by their FTO gene status. The majority of the men had low-risk versions of the gene, while 45 of the participants had mutations that have been linked to greater appetite and caloric consumption. To figure out how the altered genes were affecting appetite, the team measured levels of the hunger hormone ghrelin both before and after meals that the participants ate; the men with the mutated form of FTO did not show the same drop in ghrelin levels, signifying that they were full, as the men with the low-risk form of FTO.<\/p>\n

Genome wide association studies, which compare genetic makeups of obese individuals to those of normal weight, are making it easier to flesh out important genetic factors contributing to weight, and researchers at the Harvard School of Public Health<\/a> say that to date, these studies have\u00a0identified over 30 candidate genes on 12 chromosomes associated with body mass index.<\/p>\n

\u201cThus far mutations in about eight genes are known to cause obesity in humans. But these mutations account for under five percent of the obesity in our society, and certainly are not, by themselves, responsible for the current obesity epidemic, since the mutation rate in these genes could not have changed dramatically during the past twenty years,\u201d says Dr.\u00a0Joseph Majzoub, the chief of the division of endocrinology at Boston\u00a0Children\u2019s Hospital and an author on the Science<\/em> paper. \u201cHowever, mutations in these genes have led to the discovery of pathways that are important in energy balance in humans, giving us hope that drugs can be developed that affect these pathways to prevent excessive weight gain, either by curbing appetite or increased burning of calories.\u201d<\/p>\n

\"weight_scale\"<\/a><\/p>\n

(MORE:<\/strong> What Mice Can Tell Us About Obesity and Genetics<\/a>)<\/p>\n

Here is a round-up of some recent genes, and their products, that have been linked to obesity :<\/p>\n

Leptin:\u00a0<\/strong>Often referred to as the \u201cobesity hormone,\u201d leptin is made by fat cells and acts as a thermostat for the body\u2019s energy needs. Each individual has his own leptin threshold; if leptin levels fall below that amount, the brain understands that the body is starving, and needs more calories. If leptin levels are maintained or surge above that amount, the brain knows that it doesn\u2019t need to take in more food. Unfortunately, while mouse studies showed that overweight mice had lower levels of leptin, the same wasn\u2019t true of obese people, who generally show higher levels of leptin in their blood. Somehow, researchers how believe, these people are not getting the signal to stop eating, which is referred to as leptin-resistance.<\/p>\n

Ghrelin<\/strong>: This gene makes an appetite hormone that can make foods look more desirable\u2013especially high-calorie ones \u2014 by influencing the brain\u2019s reward system. Some studies have found that \u00a0people who are sleep-deprived have increased ghrelin levels, which may explain why lack of sleep<\/a> can contribute to weight gain.<\/p>\n

Neuropeptide Y:<\/b> One of the brain\u2019s many chemicals, neuropeptide\u00a0Y may trigger eating by manipulating appetite, possibly resulting from changes in mood and stress levels. It may also contribute to an increased deposition of fat from food calories.<\/p>\n

(MORE:\u00a0<\/strong>Childhood Obesity: Scientists Find Two Gene Variants that Predispose Kids to Weight Gain<\/a>)<\/p>\n

\"Low<\/a>
Low Carb diets taste good and are filling<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

Calvin’s Commentary: The article below is most interesting concerning the topic, “Is obesity written in our genes?” Most assuredly, I believe it is.\u00a0 I have found that the best way for people I have met and interacted with in my lifetime – those who truly struggle with a weight issue – to lose weight –…<\/p>\n","protected":false},"author":403,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2787,428,8514,4779,1614,1430,1232,2906,5388,2838,1802],"tags":[8520,8519,3811,8522,8533,8532,8535,8524,8526,8525,8515,8517,8527,8536,3288,8534,8523,8528,8516,8518,8529,8531,8530,8521],"class_list":["post-26035","post","type-post","status-publish","format-standard","hentry","category-fat-people","category-health-medicine","category-healthy-eating","category-natrual-cures","category-natural-supplements","category-news-2","category-obesity-2","category-science-2","category-sugar","category-wake-up-america","category-you-decide","tag-biology-behind-weight","tag-boston-childrens-hospital","tag-childhood-obesity","tag-diet-and-lifestyle","tag-dr-eades","tag-drs-michael-and-mary-dan-eades","tag-eliminate-type-ii-diabetes","tag-gain-weight","tag-ghrelin-levels","tag-greater-appetite-and-caloric-consumption","tag-how-much-of-weight-is-genetic","tag-journal-of-clinical-investigation","tag-leptin","tag-low-carb-diet","tag-lower-blood-pressure","tag-lower-cholesterol","tag-mrap2-gene","tag-neuropeptide-y","tag-new-genes-idd-in-obesity","tag-new-genetic-factors-that-could-explain-weight-gain-in-some-people","tag-predispose-kids-to-weight-gain","tag-protein-power","tag-scientific-study","tag-weight-is-the-complex-combination"],"yoast_head":"\nNew Genes IDd in Obesity: How Much of Weight is Genetic? - Watchwoman on the Wall<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Genes IDd in Obesity: How Much of Weight is Genetic? - Watchwoman on the Wall\" \/>\n<meta property=\"og:description\" content=\"Calvin’s Commentary: The article below is most interesting concerning the topic, “Is obesity written in our genes?” Most assuredly, I believe it is.\u00a0 I have found that the best way for people I have met and interacted with in my lifetime – those who truly struggle with a weight issue – to lose weight –…\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html\" \/>\n<meta property=\"og:site_name\" content=\"Watchwoman on the Wall\" \/>\n<meta property=\"article:published_time\" content=\"2013-07-20T00:51:29+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/blog.beliefnet.com\/watchwomanonthewall\/files\/2013\/07\/Drs.-Michael-and-Mary-Dan-Eades.jpg\" \/>\n<meta name=\"author\" content=\"Donna Calvin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New Genes IDd in Obesity: How Much of Weight is Genetic? - Watchwoman on the Wall","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html","og_locale":"en_US","og_type":"article","og_title":"New Genes IDd in Obesity: How Much of Weight is Genetic? - Watchwoman on the Wall","og_description":"Calvin’s Commentary: The article below is most interesting concerning the topic, “Is obesity written in our genes?” Most assuredly, I believe it is.\u00a0 I have found that the best way for people I have met and interacted with in my lifetime – those who truly struggle with a weight issue – to lose weight –…","og_url":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html","og_site_name":"Watchwoman on the Wall","article_published_time":"2013-07-20T00:51:29+00:00","og_image":[{"url":"http:\/\/blog.beliefnet.com\/watchwomanonthewall\/files\/2013\/07\/Drs.-Michael-and-Mary-Dan-Eades.jpg"}],"author":"Donna Calvin","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html","url":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html","name":"New Genes IDd in Obesity: How Much of Weight is Genetic? - Watchwoman on the Wall","isPartOf":{"@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html#primaryimage"},"image":{"@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html#primaryimage"},"thumbnailUrl":"http:\/\/blog.beliefnet.com\/watchwomanonthewall\/files\/2013\/07\/Drs.-Michael-and-Mary-Dan-Eades.jpg","datePublished":"2013-07-20T00:51:29+00:00","dateModified":"2013-07-20T00:51:29+00:00","author":{"@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/#\/schema\/person\/1470e1ef6765f8a27f970307b0835df1"},"breadcrumb":{"@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html#primaryimage","url":"http:\/\/blog.beliefnet.com\/watchwomanonthewall\/files\/2013\/07\/Drs.-Michael-and-Mary-Dan-Eades.jpg","contentUrl":"http:\/\/blog.beliefnet.com\/watchwomanonthewall\/files\/2013\/07\/Drs.-Michael-and-Mary-Dan-Eades.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/2013\/07\/new-genes-idd-in-obesity-how-much-of-weight-is-genetic.html#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall"},{"@type":"ListItem","position":2,"name":"New Genes IDd in Obesity: How Much of Weight is Genetic?"}]},{"@type":"WebSite","@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/#website","url":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/","name":"Watchwoman on the Wall","description":"Beliefnet Voices - Donna Calvin","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/#\/schema\/person\/1470e1ef6765f8a27f970307b0835df1","name":"Donna Calvin","description":"In sixth grade my teacher told us that we were going to be the first generation to see the year 2000 and all things would be different. He continued that God wasn't important, wasn't real, and our parents just used God to impose restrictions on us because they were inadequate to parent effectively. I knew then I was going to be involved in a war and that I would have to be in Jesus Christ's Army. Even then, I knew the United States of America would cease to exist without the vast majority of its citizens voluntarily submitting to the Perfect and Good Laws of the Holy Bible. I am a woman who loves the Lord Jesus Christ. I am tired of seeing our LORD denigrated from the school house to the White House. I search the Internet for items that ought to serve as a warning to Americans and Christians all through America, but the nation seems to be sleeping. Wake up America! You are losing your freedoms, your children and your country. Wake up and help stop it!","url":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/author\/dcalvin"}]}},"_links":{"self":[{"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/posts\/26035","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/users\/403"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/comments?post=26035"}],"version-history":[{"count":16,"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/posts\/26035\/revisions"}],"predecessor-version":[{"id":26055,"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/posts\/26035\/revisions\/26055"}],"wp:attachment":[{"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/media?parent=26035"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/categories?post=26035"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beliefnet.com\/columnists\/watchwomanonthewall\/wp-json\/wp\/v2\/tags?post=26035"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}