Nobody likes to hear this but many artificial sweeteners are associated with all sorts of health issues. Aspartame, for example, is on the FDA’s most-complained-about substance lists (but it’s still out there and in everything, particularly soda). Aspartame in particular is associated with headaches and joint pain. Other artificial sweeteners can make you crave sweets. (Ever notice how people who drink diet soft drinks generally have a weight problem?) Steer clear.