• Allergic Conjunctivitis, Allergic Pharyngitis, Allergic Rhinitis, Allergic Sinusitis, Hay Fever, Pollen Allergy, Seasonal Allergy
• Acupuncture, Adrenal Extract, Antioxidants, Ayurvedic Medicine, Bacopa Monniera (Brahmi), Barberry, Bee Pollen, Betaine Hydrochloride, Cat's Claw, Coleus forskohlii, Conjugated Linoleic Acid (CLA), Enzyme Potentiated Desensitization (EPD), Fish Oil, GLA (Gamma-linolenic Acid), Hops, Hypnosis, MSM, Nettle Leaf, Oligomeric Proanthocyanidins (OPCs), Other Flavonoids, including Citrus Bioflavonoids, Probiotics, Quercetin, Rosmarinic Acid/ Perilla Frutescens, Royal Jelly, Soy Sauce Extract (Shoyu Polysaccharides), Spirulina, Tinospora Cordifolia, Topical Capsaicin, Traditional Chinese Medicine, Vitamin B 6, Vitamin B 12, Vitamin C, Vitamin E
About 7% of all Americans suffer from hay fever, an allergic condition that can cause runny nose, sneezing, and teary eyes. It is known officially as allergic rhinitis, allergic sinusitis, or allergic conjunctivitis , depending on whether symptoms manifest mainly in the nose, sinuses, or eyes, respectively. Hay fever usually peaks when particular plants are pollinating or when molds are flourishing. People who suffer from year-round hay fever (perennial rhinitis) may be allergic to persistent allergens in the environment coming from such sources as dust mites, mice, and cockroaches.
Here's how hay fever works. In response to the triggers noted above, an individual prone to allergies develops an exaggerated immune response. Substances known as IgEs flood the nasal passages, white blood cells called eosinophils arrive by the millions and billions, and inflammatory substances such as histamine, prostaglandins, and leukotrienes are released in massive amounts. The overall effect is the familiar one of swelling, dripping, itching, and aching.
The mechanism of allergic response is fairly well understood. Why allergic people react so excessively to innocent bits of pollen, however, remains a complete mystery.
Conventional treatment for hay fever primarily involves nonsedating antihistamines and nasal steroids and is usually quite effective.
Principal Proposed Natural Treatments
The herb butterbur is best known as a promising new treatment for migraine headaches . However, butterbur may also be helpful for allergic rhinitis.
In a 2-week, double-blind, placebo-controlled study of 186 people with intermittent allergic rhinitis, use of butterbur at a dose of three standardized tablets daily, or one tablet daily, reduced allergy symptoms as compared to placebo. 34 Significantly greater benefits were seen in the higher dose group. Such "dose dependency" is taken as a confirming sign that a treatment really works.
In another double-blind study, 330 people were given either butterbur extract (one tablet three times daily), the antihistamine fexofenadine (Allegra), or placebo. 44 The results showed that butterbur and fexofenadine were equally effective, and both were more effective than placebo.
A previous 2-week, double-blind study of 125 individuals with hay fever (technically, seasonal allergic rhinitis) compared a standardized butterbur extract against the antihistamine drug certizine. 18 According to ratings by both doctors and patients, the two treatments proved about equally effective. Unfortunately, this study did not use a placebo group.
Two much smaller studies produced inconsistent results. 27,35
For more information, including dosage and safety issues, see the full Butterbur article.
An alternative to allergy shots known as sublingual immunotherapy (SLIT) involves using allergenic substances placed under the tongue. Numerous double-blind, placebo-controlled studies indicate that SLIT can improve all major symptoms of allergic rhinitis when the offending allergens are known.32,43,48,49,51,63,68,69 However, in a 2008 comprehensive review of SLIT for grass pollen and house dust mite allergies, researchers raised questions regarding the quality and consistency of these and other studies.65
If SLIT is effective, it may require 2-3 years for significant benefit to develop.54 One placebo-controlled study found that 3 years of treatment was more effective than 2 years.56 In addition, to provide benefits for grass allergy season, SLIT must be started at least 8 weeks prior to the onset of the grass allergy season; even longer lead times lead to even better results.58 Putting all this evidence together, it appears that SLIT may work best if used year round, and year-after-year.
While SLIT is fairly well accepted in conventional medicine, another form of “alternative” allergy shots remains firmly in the alternative medicine field: enzyme potentiated desensitisation (EPD). This method involves injections of allergens combined with certain enzymes. In one double-blind, placebo-controlled study, EPD failed to prove more helpful than placebo for seasonal allergic rhinitis.33
Other Proposed Natural Treatments
Several natural products have shown potential benefit for allergic rhinitis in one or more preliminary controlled trials. These include a water-extract of hops , a freeze-dried extract of stinging nettle , 1 various probiotics , 36,52,57 an extract of soy sauce (Shoyu polysaccharides), 37,38 the herb Tinospora cordifolia , 39 rosmarinic acid (a substance found in the herb rosemary , and many other herbs, including Perilla frutescens ), 28,40 and an Ayurvedic herbal formula containing Commiphora mukul , Tinospora cordifolia , Rubia cordifolia , Emblica officinalis , Moringa pterygosperma , and Glycyrrhiza glabra . 19,22
Traditional Chinese herbal medicine has shown some promise for allergies as well. 23,24,29 Another traditional Chinese treatment, acupuncture , is commonly recommended for allergies, but a controlled trial of 40 people failed to find significantly more benefit with real acupuncture than with fake acupuncture. 30 However, another study found benefit with real acupuncture plus real traditional Chinese herbs as opposed to placebo acupuncture and nonspecific Chinese herbs. 41 A carefully conducted review of 7 placebo-controlled trials failed to find convincing evidence for acupuncture’s effectiveness against allergic rhinitis.67
One rather unusual study tested a nasal spray containing capsaicin, the “hot” in cayenne and other hot peppers. 31 It’s not clear how practical this is—researchers had to use local anesthetic in the nose prior to using the spray!
A 12-week, double-blind, placebo-controlled study of 40 people tested the supplement conjugated linoleic acid (CLA) as a treatment for people with allergies to birch pollen and found some evidence of benefit.62
Test tube studies suggest that flavonoids—biologically active compounds found in many plants—may help reduce allergy symptoms. 2-5 A particular flavonoid, quercetin , seems to be one of the most active. 6-11 Many texts on natural medicine claim that quercetin works like the drug cromolyn (Intal), by stopping the release of allergenic substances in the body. However, while we have direct evidence that cromolyn is effective, there have not been any published studies in which people were given quercetin and their allergic symptoms decreased. It is a long way from test tube studies to real people.
Tomato extract has been advocated for the treatment of allergic rhinitis, but the one double-blind study said to demonstrate benefit actually proves almost nothing at all due to major flaws in its statistical analysis. 55
Oligomeric Proanthocyanidins (OPCs) from grape seed or pine bark are also often said to be effective. However, an 8-week, double-blind trial of 49 individuals found no benefit from grape seed extract (dose not stated). 12
The last several substances discussed (vitamins E and C, flavonoids, and OPCs) are antioxidants . One study failed to find evidence of benefit with a mixture of antioxidants: beta-carotene (9 mg/day), vitamin C (1500 mg/day), vitamin E (130 mg/day), zinc (45 mg/day), selenium (76 mg/day), and garlic (150 mg/day). 53
Adrenal extracts , bee pollen , Bacopa monniera (brahmi) , barberry , vitamin B 6 , vitamin B 12 , cat's claw , Coleus forskohlii , gamma-linolenic acid (GLA) , fish oil , methyl sulfonyl methane (MSM) , and betaine hydrochloride are sometimes recommended for hay fever, but there is as yet no significant evidence that they are effective.
It has often been suggested that consumption of honey can reduce symptoms of hay fever. However, the one published study designed to test this suggestion failed to find benefit. 50 Another study failed to find the bee product royal jelly effective. 59
Acupuncture has also shown some promise for allergic rhinitis.46 In a randomized, placebo-controlled trial enrolling 80 adult subjects, real acupuncture was superior to sham acupuncture after 8 weeks of treatment for symptoms of persistent allergic rhinitis.64
This topic is also discussed in the Homeopathy database, under the chapter on hay fever.
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8. Pearce FL, Befus AD, Bienenstock J. Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. J Allergy Clin Immunol. 1984;73:819-823.
12. Bernstein CK, Deng C, Shuklah R, et al. Double blind placebo controlled (DBPC) study of grapeseed extract in the treatment of seasonal allergic rhinitis (SAR) [abstract]. J Allergy Clin Immunol. 2001;107:1018.
23. Japan's Health Ministry confirms efficacy of another of Tsumura's Kampo drugs. Kampo Today [serial online]. 2000:4. Available at: http://www.tsumura.co.jp/english/kthp/4-1-01.htm . Accessed November 4, 2002.
24. Hu G, Walls RS, Bass D, et al. The Chinese herbal formulation biminne in management of perennial allergic rhinitis: a randomized, double-blind, placebo-controlled, 12-week clinical trial. Ann Allergy Asthma Immunol. 2002;88:478-487.
27. Lee DK, Gray RD, Robb FM, et al. A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy. 2004;34:646-649.
28. Takano H, Osakabe N, Sanbongi C, et al. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp Biol Med (Maywood). 2004;229:247-54.
31. Van Rijswijk JB, Boeke EL, Keizer JM, et al. Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study. Allergy. 2003;58:754-761.
34. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol Head Neck Surg. 2004;130:1381-1386.
36. Ishida Y, Nakamura F, Kanzato H, et al. Clinical effects of Lactobacillus acidophilus Strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study. J Dairy Sci. 2005;88:527-533.
37. Kobayashi M, Matsushita H, Shioya I, et al. Quality of life improvement with soy sauce ingredients, Shoyu polysaccharides, in perennial allergic rhinitis: a double-blind placebo-controlled clinical study. Int J Mol Med. 2004;14:885-889.
38. Kobayashi M, Matsushita H, Tsukiyama R, et al. Shoyu polysaccharides from soy sauce improve quality of life for patients with seasonal allergic rhinitis: a double-blind placebo-controlled clinical study. Int J Mol Med. 2005;15:463-467.
40. Osakabe N, Takano H, Sanbongi C, et al. Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism. Biofactors. 2005;21:127-131.
41. Brinkhaus B, Hummelsberger J, Kohnen R, et al. Acupuncture and Chinese herbal medicine in the treatment of patients with seasonal allergic rhinitis: a randomized-controlled clinical trial. Allergy. 2004;59:953-690.
45. Montano Velazquez BB, Jauregui-Renaud K, Banuelos Arias Adel C, et al. Vitamin E effects on nasal symptoms and serum specific IgE levels in patients with perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2006;96:45-50.
48. Penagos M, Compalati E, Tarantini F, et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol. 2006;97:141-148.
51. Rak S, Yang WH, Pedersen MR, et al. Once-daily sublingual allergen-specific immunotherapy improves quality of life in patients with grass pollen-induced allergic rhinoconjunctivitis: a double-blind, randomised study. Qual Life Res. 2006 Oct 11. [Epub ahead of print]
52. Tamura M, Shikina T, Morihana T, et al. Effects of probiotics on allergic rhinitis induced by Japanese cedar pollen: randomized, double-blind, placebo-controlled clinical trial. Int Arch Allergy Immunol. 2006 Dec 29. [Epub ahead of print]
53. Dunstan JA, Breckler L, Hale J, et al. Supplementation with vitamins C, E, beta-carotene, and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trial. Clin Exp Allergy. 2007;37:180-187.
57. Giovannini M, Agostoni C, Riva E, et al. A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Pediatr Res. 2007 Jun 25. [Epub ahead of print]
60. Segawa S, Takata Y, Kaneda H, et al. Effects of a hop water extract on the compound 48/80-stimulated vascular permeability in ICR mice and histamine release from OVA-sensitized BALB/c mice. Biosci Biotechnol Biochem. 2007;71:1577-1581.
61. Segawa S, Takata Y, Wakita Y, et al. Clinical effects of a hop water extract on Japanese Cedar Pollinosis during the pollen season: a double-blind, placebo-controlled trial. Biosci Biotechnol Biochem. 2007 Aug 7. [Epub ahead of print]
62. Turpeinen AM, Ylonen N, von Willebrand E, et al. Immunological and metabolic effects of cis-9, trans-11-conjugated linoleic acid in subjects with birch pollen allergy. Br J Nutr. 2008 Jan 2. [Epub ahead of print]
63. Mosges R, Bruning H, Hessler HJ, et al. Sublingual immunotherapy in pollen-induced seasonal rhinitis and conjunctivitis: a randomized controlled trial. Acta Dermatovenerol Alp Panonica Adriat. 2007;16:143-148.
65. Hoeks SB, de Groot H, Hoekstra MO. Sublingual immunotherapy in children with asthma or rhinoconjunctivitis: not enough evidence because of poor quality of the studies; a systematic review of literature. Ned Tijdschr Geneeskd. 2008;152:261-268.
68. Pfaar O, Klimek L. Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trial. Ann Allergy Asthma Immunol. 2008;100:256-263.
69. Dahl R, Kapp A, Colombo G, et al. Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years. J Allergy Clin Immunol. 2008;121:512-518.e2.
Last reviewed May 2008 by EBSCO CAM Medical Review Board
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