Beta-blockers are used for hypertension as well as for a variety of heart conditions.
Drugs that fall into this family include
- Acebutolol hydrochloride (Sectral)
- Atenolol (Tenormin)
- Betaxolol hydrochloride (Kerlone)
- Bisoprolol fumarate (Zebeta)
- Carteolol (Cartrol)
- Carvedilol (Coreg)
- Esmolol hydrochloride (Brevibloc)
- Labetalol hydrochloride (Normodyne, Trandate)
- Metoprolol (Lopressor, Toprol XL)
- Nadolol (Corgard)
- Penbutolol (Levatol)
- Pindolol (Visken)
- Propranolol hydrochloride (Betachron E-R, Inderal, Inderal LA)
- Sotalol (Betapace)
- Timolol maleate (Blocadren)
- and others
Supplementation Possibly Helpful
There is some evidence that beta-blockers (specifically propranolol, metoprolol, and alprenolol) might impair the body's ability to utilize the substance coenzyme Q10 (CoQ10).1,2 This is particularly worrisome, because CoQ10 appears to play a significant role in normal heart function. 3 Depletion of CoQ10 might be responsible for some of the side effects of beta-blockers. In one study, CoQ10 supplements reduced side effects caused by the beta-blocker propranolol.4 The beta-blocker timolol may interfere with CoQ10 production to a lesser extent than other beta-blockers.
The herb Coleus forskohlii relaxes blood vessels and might have unpredictable effects on blood pressure if combined with beta-blockers.
2. Kishi T, et al. Bioenergetics in clinical medicine. XV. Inhibition of coenzyme Q10 -enzymes by clinically used adrenergic blockers of beta receptors. Res Commun Chem Pathol Pharmacol. 1977;17:157-164.
4. Hamada M, Kazatain Y, Ochi T, et al. Correlation between serum CoQ10 level and myocardial contractility in hypertensive patients. In: Biomedical and Clinical Aspects of Coenzyme Q, Vol 4. Amsterdam: Elsevier; 1984: 263-270.
5. Roeback JR, et al. Effects of chromium supplementation on serum high-density lipoprotein cholesterol levels in men taking beta-blockers. A randomized, controlled trial. Ann Intern Med. 1991;115:917-924.
Last reviewed October 2007 by EBSCO CAM Review Board
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