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Gangrene
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Gangrene

(Dry Gangrene; Gas Gangrene; Organ or Tissue Death; Wet Gangrene)

En Español (Spanish Version)

Definition

Gangrene is the death of an organ or body tissue. When the blood supply is cut off, the tissue doesn't get enough oxygen and begins to die. If the gangrene is widespread, shock can occur.

There are three main types:

  • Dry gangrene—lack of blood supply causes the tissue to dry up and slough off
  • Wet gangrene—usually occurs when the tissue is infected with bacteria, tissue becomes moist and breaks down
  • Gas gangrene—a particular type of bacteria ( Clostridia ) produces gas bubbles in the tissue

Causes

Causes of gangrene include:

  • Infection, especially after surgery or injury
  • Diabetes
  • Any condition that blocks the blood flow to the tissues (eg, atherosclerosis )

Risk Factors

These factors increase your chance of developing gangrene. Tell your doctor if you have any of these:

Symptoms

Symptoms may include:

  • Swelling
  • Pain, followed by numbness when the tissue is dead
  • Sloughing off of skin
  • Color changes, ranging from white, to red, to black
  • Shiny appearance to skin
  • Frothy, clear, watery discharge
  • Fever and chills
  • Nausea and vomiting

Gangrene of the Foot

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© 2008 Nucleus Medical Art, Inc.

Diagnosis

The doctor will ask about your symptoms and medical history, and perform a physical exam.

Tests may include:

  • Blood tests
  • Tests of the discharge and the tissue
  • X-rays —a test that uses radiation to take pictures of structures inside the body
  • CT scan —a type of x-ray that uses a computer to make pictures of the inside of the body
  • MRI scan —a test that uses magnetic waves to make pictures of the inside of the body

Treatment

Treatment of gangrene includes:

Prevention

To help prevent gangrene:

  • If you have diabetes, take good care of your hands and feet.
  • If you need surgery, ask you doctor about taking antibiotics. This is especially true if you need intestinal surgery.

RESOURCES:

American Academy of Family Physicians
http://www.aafp.org/

American Diabetes Association
http://www.diabetes.org/home.jsp/

CANADIAN RESOURCES:

Canadian Diabetes Association
http://www.diabetes.ca/

Health Canada
http://www.hc-sc.gc.ca/index_e.html/

References:

Cecil RL, Goldman L, Bennett JC. Cecil Textbook of Medicine . 21st ed. Philadelphia, PA: WB Saunders Company; 2000.

Conn HF, Rakel RE. Conn's Current Therapy 2001 . 53rd ed. Philadelphia, PA: WB Saunders Company; 2001.

Gas gangrene. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated June 2008. Accessed June 24, 2008.

Mandell GL, Douglas RG, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases . 5th ed. Philadelphia, PA: Churchill Livingstone; 2000.

Rosen P, et al. Emergency Medicine: Concepts and Clinical Practice . 4th ed. St. Louis, MO: Mosby-Year Book; 2000.



Last reviewed November 2007 by David L. Horn, MD, FACP

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.


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