Diabetic Nephropathy

(Nephropathy, Diabetic; Diabetic Glomerulosclerosis)


Diabetic nephropathy is kidney damage that occurs with diabetes. It is the job of the kidneys to:
  • Filter blood
  • Catch needed substances and return them to circulation
  • Create urine to pass waste out of the body
Damage from diabetes can prevent the kidneys from working well. In some cases, this can lead to kidney failure .
Anatomy of the Kidney
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Blood passes through small filters in the kidneys. Changes in the blood vessels due to diabetes can cause damage to these filters. Blood sugar levels that are not well-controlled can have the greatest impact on the kidney filters.Over time, the damage to the filters increases. The damaged filters cannot clean the blood properly and protein from the blood can leak into the urine. If left untreated, this can lead to kidney failure.

Risk Factors

Factors that may increase your chance of diabetic nephropathy include Type 1 diabetes and Type 2 diabetes with:


Symptoms may not appear until the kidney damage is severe. Symptoms may include:
  • Fluid buildup may appear as swelling in feet or hands
  • Weakness
  • Loss of appetite
  • Difficulty sleeping
  • Confusion and trouble concentrating

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