Tetralogy of Fallot
DefinitionTetralogy of Fallot (TOF) is a combination of 4 heart defects. It is present at birth. These defects make it difficult for your child to get oxygen to the entire body.The defects are:
- Ventricular septal defect (VSD)—A hole in the heart. It is on a wall that separates the 2 lower chambers.
- Overriding aorta—The aorta, which is the body's largest artery coming out of the left ventricle, partially covers or comes out of the right ventricle.
- Pulmonary stenosis—The valve in the heart that allows blood to pass from the heart toward the lungs is too narrow.
- Right ventricular hypertrophy—The muscle on the right side of the heart is too thick.
CausesA child's heart develops very early in pregnancy. Tetralogy of Fallot is caused by a problem during this development. It is not known exactly why these problems happen. Some have been associated with genetics, mother's nutrition, or infections. Most have no known cause.
|Ventricular Septal Defect|
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Risk FactorsFactors that may increase the risk of Tetralogy of Fallot (TOF) include:
- Family history
- Mother's use of retinoic acid
- Mother's use of oral fluconazole
- Mother's alcohol use
- Mother has infection with rubella
- Pregnancy in mothers over 40
- Maternal diabetes
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