Primidone

Trade Names :

  • Mysoline

Folate - Supplementation Possibly Helpful Vitamin D - Supplementation Possibly Helpful Vitamin K - Supplementation Possibly Helpful for Pregnant Women Biotin - Supplementation Possibly Helpful, but Take at a Different Time of Day Glutamine - Theoretical Harmful Interaction Vitamin B3 - Potentially Dangerous Interaction St. John's Wort, Dong Quai - Possible Harmful Interaction Ginkgo - Possible Harmful Interaction Kava, Valerian, Passionflower, Hops - Possible Harmful Interaction

Like phenobarbital, to which it is closely related, primidone is used to control epileptic seizures.

Folate Primidone can reduce folate levels perhaps by increasing the rate of breakdown of the vitamin. Over time, such a decrease can cause anemia. 1–5 Taking folate supplements will correct this anemia. 6 Anticonvulsant-induced folate deficiency might also cause birth defects. Women who plan to become pregnant while on primidone should be sure to take a supplement to prevent deficiency. 7,8

Vitamin D Primidone appears to interfere with the normal absorption or metabolism of vitamin D. 9,10 This in turn impairs calcium absorption, with many potential complications. 11 To help avoid this problem, you should make sure that you get enough vitamin D.

Vitamin K Children born to women taking primidone while pregnant may be deficient in vitamin K. 12,13 This might lead to bleeding disorders and facial bone abnormalities. Supplementing with vitamin K during pregnancy should help; however, physician supervision is recommended.

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