Trade Names:

  • Trental

Chondroitin - Possible Harmful Interaction Garlic, Ginkgo - Possible Harmful Interaction PC-SPES - Possible Harmful Interaction Policosanol - Possible Harmful Interaction Reishi - Possible Harmful Interaction Vinpocetine - Possible Harmful Interaction White Willow - Possible Harmful Interaction Herbs and Supplements - Possible Harmful Interaction

Pentoxifylline, a drug that makes the blood less "sticky," is used to increase blood circulation in conditions such as intermittent claudication (a possible complication of atherosclerosis in which impaired blood circulation causes severe pain in calf muscles during walking or exercising).

Chondroitin Based on chondroitin’s chemical similarity to the anticoagulant drug heparin, it has been suggested that chondroitin might have anticoagulant effects as well. There are no case reports of any problems relating to this, and studies suggest that chondroitin has at most a mild anticoagulant effect. 16 Nonetheless, prudence suggests that chondroitin should not be combined with pentoxifylline except under physician supervision.

GarlicGinkgo The herb garlic (Allium sativum) is taken to lower cholesterol, among many other proposed uses. One of the possible side effects of garlic is an increased tendency to bleed. 1,2 Therefore, you should not combine garlic and pentoxifylline except under medical supervision. The herb ginkgo (Ginkgo biloba) has been used to treat Alzheimer's disease and ordinary age-related memory loss, among many other uses. Ginkgo appears to reduce the ability of platelets (blood-clotting cells) to stick together. 3 Several case reports suggest that this blood-thinning effect of ginkgo may be associated with an increased risk of serious abnormal bleeding episodes in individuals taking the herb. 4,5,6Because of these risks, you should not combine ginkgo and pentoxifylline without physician supervision.

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