Supplement Forms/Alternate Names

  • Red Clover Isoflavones
  • Soy Isoflavones


Principal Proposed Uses

Other Proposed Uses

Isoflavones are water-soluble chemicals found in many plants. In this article, we will discuss a group of isoflavones that are phytoestrogens, meaning that they cause effects in the body somewhat similar to those of estrogen. The most investigated phytoestrogen isoflavones, genistein and daidzein, are found both in soy products and the herb red clover . Soy additionally contains glycitein, an isoflavone that is more estrogenic than genistein and daidzein, but is usually present in relatively low amounts. Red clover also contains two other isoflavones: biochanin (which can be turned into genistein) and formonenetin (which can be turned into daidzein). Certain cells in the body have estrogen receptors , special sites that allow estrogen to attach. When estrogen attaches to a cell’s estrogen receptor, estrogenic effects occur in the cell. Isoflavones latch onto estrogen receptors too, but produce weaker estrogenic effects. This leads to an interesting two-part action. When there is not enough estrogen in the body, isoflavones can stimulate cells with estrogen receptors and partly make up for the deficit. However, when there is plenty of estrogen, isoflavones may tend to block real estrogen from attaching to estrogen receptors, thereby reducing the net estrogenic effect. This may reduce some of the risks of excess estrogen (for example, breast and uterine cancer) while still providing some of estrogen's benefits (such as, preventing osteoporosis). Isoflavones also appear directly to reduce estrogen levels in the body, perhaps by fooling the body into thinking that it has plenty of estrogen. Isoflavones are widely thought to be the active ingredients in soy products . However, growing evidence suggests that there are other active ingredients as well, such as proteins, fiber, and phospholipids.

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