Monoamine Oxidase Inhibitors

Ephedra —Dangerous Interaction Scotch Broom —Dangerous Interaction Green Tea —Probable Dangerous Interaction Ginseng —Possible Dangerous Interaction St. John's Wort —Possible Dangerous Interaction S-Adenosylmethionine (SAMe) and Hydroxytryptophan (5-HTP) —Possible Dangerous Interactions

Monoamine oxidase (MAO) inhibitors were the first antidepressant drugs invented. While they are quite effective, they can be dangerous if combined with the wrong foods, drugs, or supplements. The substance tyramine, found in some cheeses, beer, fermented soy products, and other foods, is particularly dangerous to combine with these medications. Stimulant drugs such as pseudoephedrine can also cause problems.Antidepressants in this family include furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine sulfate (Nardil), and tranylcypromine sulfate (Parnate) among others.

Ephedra Because it contains the stimulant ephedrine, combining the herb ephedra with MAO inhibitors can rapidly produce a severe, dangerous interaction and must be avoided. 1 In the US, it is illegal to sell products containing ephedra.

The herb scotch broom contains high levels of tyramine, so it should not be taken with MAO inhibitors. 2

Green TeaBecause it contains caffeine, green tea should not be combined with MAO inhibitors.

Ginseng According to one report, the combination of ginseng and the MAO inhibitor phenelzine caused worrisome symptoms. 3 While this may have been due to caffeine contamination of the ginseng, we would recommend that you avoid ginseng–MAO inhibitor combinations at this time.

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