H2 Blockers

Vitamin B12 - Probable Need for Supplementation Folate - Supplementation Possibly Helpful Minerals - Supplementation Possibly Helpful Magnesium - Take at a Different Time of Day Vitamin D - Possible Inhibition by Cimetidine

Medications in this family sharply decrease stomach acid production. They are widely used for the treatment of ulcers as well as for mild cases of esophageal reflux (heartburn).Drugs that fall into this family include

  • cimetidine (Tagamet, Tagamet HB)
  • famotidine (Pepcid, Pepcid AC, Pepcid RPD)
  • nizatidine (Axid, Axid AR)
  • ranitidine hydrochloride (Zantac, Zantac EFFERdose, Zantac GELdose, Zantac 75)
  • and others

Vitamin B12 H 2 -receptor blockers appear to impair the absorption of vitamin B 12 from food. 1,2,3 This is thought to occur because the vitamin B 12 in food is attached to proteins. Stomach acid separates them and allows the B 12 to be absorbed. The solution? If you regularly use H 2 blockers, take B 12 supplements. They can be absorbed easily because they are not attached to proteins.

Folate There is some evidence that H 2 blockers may slightly reduce the absorption of folate. 4 Folate is an important nutrient and one that is commonly deficient in the diet; so if you are taking H 2 blockers, you should probably take folate supplements, too.

By reducing stomach acid levels, H 2 blockers might interfere with the absorption of iron , zinc , and perhaps other minerals. 5–8 Taking mineral supplements that provide the U.S. Dietary Reference Intake (formerly known as the Recommended Dietary Allowance) of these substances should help.

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