Penicillamine

Trade Names :

  • Cuprimine
  • Depen

Copper - Avoid in Cases of Wilson's Disease Vitamin B6 - Possible Need for Supplementation Zinc - Supplementation Possibly Helpful, but Take at a Different Time of Day Iron - Take at a Different Time of Day

The drug penicillamine is primarily used to treat Wilson's disease (an inherited disorder affecting copper metabolism, causing cirrhosis and brain and eye problems) and rheumatoid arthritis. 

CopperWhen used to treat Wilson's disease, penicillamine works by removing copper from the body. Taking copper supplements while you are using penicillamine for this condition is not a good idea.

Vitamin B6 Penicillamine might increase the need for vitamin B 6 . 1 Taking 25 to 50 mg of supplemental B 6 daily is often recommended. 2

Zinc Long-term use of penicillamine can cause zinc deficiency. 3 However, zinc can impair penicillamine absorption, so do not take zinc supplements during the 2 hours before or after your penicillamine dose. 4

Iron Penicillamine attaches to the mineral iron, which impairs the absorption of both substances. 5,6 The solution: If you need iron supplements, do not take them during the 2 hours before or after your penicillamine dose.

References

1
Rumsby PC and Shepherd DM. The effect of penicillamine on vitamin B 6 function in man. Biochem Pharmacol 30: 3051–3053, 1981.

2
Pronsky Z (ed.). Powers and Moore's food medication interactions, 10th ed. Pottstown, PA: Food-Medication Interactions, 1997: 182.

3
Multicentre Trial Group. Controlled trial of D(-) penicillamine in severe rheumatoid arthritis. Lancet 1: 275–280, 1973.

4
Pronsky Z (ed.). Powers and Moore's food medication interactions, 10th ed. Pottstown, PA: Food-Medication Interactions, 1997: 182.

5
Campbell NR and Hasinoff BB. Iron supplements: a common cause of drug interactions. Br J Clin Pharmacol 31(3): 251–255, 1991.

6
Pronsky Z (ed.). Powers and Moore's food medication interactions, 10th ed. Pottstown, PA: Food-Medication Interactions, 1997: 182.

Revision Information

leave comments
0
Did you like this? Share with your family and friends.
Related Topics: Health And Healing
Meet Our Health Experts
beginners heart

Beginner's Heart

Britton Gildersleeve
New! poetry as mentor

Mindfulness Matters

Arnie Kozak
New! How to Create Solitude in the Context of Relationship

Our Lady of Weight Loss

Janice Taylor
New! OneWord 8 Quotes Guaranteed to Bring a Tear to the Eye


Advertisement

Our Free Newsletter
click here to see all of our uplifting newsletters »

 

Advertisement

DiggDeliciousNewsvineRedditStumbleTechnoratiFacebook