Phenothiazines

Coenzyme Q 10 (CoQ 10 ) —Supplementation Possibly Helpful Milk Thistle —Possible Helpful Interaction Fish Oil —Possible Helpful Interaction
Ginkgo —Possible Helpful Interaction Vitamin E —Possible Helpful Interaction Vitamin B6 —Possible Helpful Interaction DHEA —Possible Helpful Interaction Glycine —Possible Helpful Interaction Phenylalanine —Possible Increased Risk of Tardive Dyskinesia Kava —Possible Increased Risk of Dystonic Reactions St. John's Wort, Other Herbs —Potential Increased Risk of Photosensitivity Yohimbe —Possible Dangerous Interaction

Phenothiazine drugs are primarily used for the treatment of schizophrenia and other forms of psychosis.Medications in this family include

  • Chlorpromazine hydrochloride (Thorazine)
  • Fluphenazine (Permitil, Prolixin)
  • Mesoridazine besylate (Serentil)
  • Perphenazine (Trilafon)
  • Prochlorperazine (Compazine)
  • Promazine hydrochloride (Sparine)
  • Promethazine hydrochloride (Anergan [injectable], Phenergan)
  • Thioridazine hydrochloride (Mellaril)
  • Trifluoperazine hydrochloride (Stelazine)
  • Triflupromazine hydrochloride (Vesprin [injectable])
  • and others

Coenzyme Q 10 (CoQ 10 ) Preliminary studies suggest that phenothiazine drugs might deplete the body of coenzyme Q 10 (CoQ 10 ). 1,2 While there is as yet no evidence that taking CoQ 10 supplements provides any specific benefit, supplementing with CoQ 10 on general principle might be a good idea if you are taking phenothiazine drugs.

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