Thiazide Diuretics

Potassium —Probable Need for Supplementation Magnesium —Supplementation Possibly Helpful Calcium —Possible Dangerous Interaction Coenzyme Q 10 (CoQ 10 ) —Supplementation Possibly Helpful Zinc —Supplementation Possibly Helpful Licorice —Possible Dangerous Interaction

Thiazide diuretics are commonly used to treat hypertension . Drugs in this family include:

  • Bendroflumethiazide (Naturetin)
  • Benzthiazide (Exna)
  • Chlorothiazide (Diurigen, Diuril)
  • Chlorthalidone (Hygroton, Thalitone)
  • Hydrochlorothiazide (Esidrix, Ezide, HydroDIURIL, Hydro-Par, Microzide, Oretic)
  • Hydroflumethiazide (Diucardin, Saluron)
  • Indapamide (Lozol)
  • Methyclothiazide (Aquatensen, Enduron)
  • Metolazone (Mykrox,  Zaroxolyn)
  • Polythiazide (Renese)
  • Quinethazone (Hydromox)
  • Trichlormethiazide (Diurese, Metahydrin, Naqua)
  • and others

PotassiumThiazide diuretics cause a constant and significant loss of potassium. The classic treatment for this is to eat bananas and drink orange juice. Potassium supplements are also frequently prescribed.Medications that combine thiazides and potassium-sparing diuretics might produce an unpredictable effect on potassium levels in the body. If you are taking such medications, do not increase your potassium intake except on the advice of your physician.

Magnesium Long-term use (more than 6 months) of thiazide diuretics might lead to magnesium deficiency. 1,2,3 In turn, this loss of magnesium can increase the depletion of potassium. 4Since magnesium deficiency is common anyway, if you take thiazide diuretics it would certainly make sense to take magnesium supplements at the US Dietary Reference Intake dosage.

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