Calcium Channel Blockers

Calcium and Vitamin D —Possible Decreased Action of Drug Ginkgo Biloba —Possible Decreased Action of Drug Naringen (a Citrus Bioflavonoid)—May Necessitate Reduction of Drug Dosage

Calcium channel–blockers are used to treat hypertension , angina , heart arrhythmias , and other heart-related conditions. Examples of drugs in this family include:

  • Amlodipine (Norvasc)
  • Bepridil hydrochloride (Vascor)
  • Diltiazem (Cardizem, Cardizem CD, Cardizem SR, Dilacor XR, Tiamate, Tiazac)
  • Felodipine (Plendil)
  • Isradipine (DynaCirc, DynaCirc CR)
  • Nicardipine hydrochloride (Cardene, Cardene SR)
  • Nifedipine (Procardia, Procardia XL, Adalat, Adalat CC)
  • Nimodipine (Nimotop)
  • Nisoldipine (Sular)
  • Verapamil (Calan, Calan SR, Covera-HS, Isoptin, Isoptin SR, Verelan)

CalciumVitamin D Taking calcium and vitamin D supplements might interfere with some of the effects of calcium channel-blockers. 1-7Ginkgo Biloba According to a study in rats, ginkgo extract may cause the body to metabolize some calcium channel blockers more rapidly, thereby decreasing their effects. 8

Citrus Bioflavonoid Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug. 9 This may necessitate a reduction in drug dosage.


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