Trimethoprim/Sulfamethoxazole

Alternate Names :

  • TMP-SMZ

Trade Names :

  • Bactrim
  • Cotrim
  • Septra
  • Sulfatrim

Folate - Supplementation Likely Helpful PABA (Para-Aminobenzoic Acid) - Interference with Action of Drug Potassium - Possible Harmful Interaction White Willow - Possible Negative Interaction St. John's Wort, Other Herbs - Potential Increased Risk of Photosensitivity

See also Antibiotics (General)Trimethoprim (Proloprim, Trimpex) is commonly combined with sulfamethoxazole (Gantanol) for an antibiotic combination that gives a one-two punch against bacteria.

FolateBoth trimethoprim and sulfamethoxazole interfere with folate: The sulfamethoxazole makes it hard for invading bacteria to manufacture folate, and the trimethoprim makes it hard for bacteria to use the folate. The net effect is to starve the bacteria of this necessary vitamin. Humans and other mammals are much less affected by these antibiotics than are bacteria, due to the different way we process folate. However, trimethoprim can still interfere to some extent in your body's ability to utilize this essential nutrient. Folate supplementation may be helpful if you take this antibiotic for a long period of time (to prevent urinary tract infections, for example). 1

PABA (Para-Aminobenzoic Acid) The supplement PABA may make trimethoprim/sulfamethoxazole less effective. If you are being treated with this drug, do not take PABA except on medical advice. 2,3

Potassium Trimethoprim/sulfamethoxazole might increase levels of potassium in the body. 4 Therefore, if you are on long-term treatment with this antibiotic, you should not take potassium supplements except on the advice of a physician.

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