Nonsteroidal Anti-inflammatory Drugs

Arginine —Possible Harmful Interaction Feverfew —Possible Harmful Interaction Garlic, Ginkgo —Possible Harmful Interaction Policosanol, Sugarcane Source —Possible Harmful Interaction PC-SPES —Possible Harmful Interaction Potassium Citrate —Possible Harmful Interaction Reishi —Possible Harmful Interaction St. John's Wort, Dong Quai —Possible Harmful Interaction Vinpocetine —Possible Harmful Interaction Vitamin E —Possible Mixed Interaction White Willow —Possible Harmful Interaction Herbs and Supplements —Possible Harmful Interaction Citrate—Possible Harmful InteractionCayenne —Supplementation Possibly Helpful Colostrum —Supplementation Possibly Helpful Folate —Supplementation Possibly Helpful Licorice —Supplementation Possibly Helpful Vitamin C —Supplementation Possibly Helpful Policosanol, Beeswax Source —Possible Helpful Interaction Chondroitin —Possible Harmful Interaction

Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain, fever, and inflammation. Traditional NSAIDs block COX-1 and COX-2 enzymes that the body uses to manufacture substances called prostaglandins. Since COX-1 prostaglandins are stomach-protective, blocking this enzyme is associated with gastrointestinal toxicity, a known side effect of these drugs. Newer NSAIDs (called COX-2 inhibitors) block primarily COX-2 prostaglandins associated with pain, fever, and inflammation, and might be less risky to the stomach. However, this is not proven, and some COX-2s have been taken off the market due to excess risk of heart attacks attributable to their use. Drugs in this family include:

  • Aspirin, alternatively called acetylsalicylic acid or ASA (Adprin-B, Anacin, Arthritis Foundation Aspirin, Ascriptin, Aspergum, Asprimox, Bayer, BC, Bufferin, Buffex, Cama, Cope, Easprin, Ecotrin, Empirin, Equagesic, Fiorinal, Fiorital, Halfprin, Heartline, Genprin, Lanorinal, Magnaprin, Measurin, Micrainin, Momentum, Norwich, St. Joseph, Zorprin)
  • Celecoxib (Celebrex)
  • Choline salicylate (Arthropan)
  • Choline salicylate/magnesium salicylate (Tricosal, Trilisate)
  • Diclofenac potassium (Cataflam, Voltaren Rapide)
  • Diclofenac sodium (Arthrotec, Voltaren, Voltaren SR, Voltaren-XR)
  • Diclofenac sodium/misoprostol (Arthrotec)
  • Diflunisal (Dolobid)
  • Etodolac (Lodine, Lodine XL)
  • Fenoprofen calcium (Nalfon)
  • Flurbiprofen (Ansaid)
  • Ibuprofen (Advil, Arthritis Foundation Ibuprofen, Bayer Select Ibuprofen, Dynafed IB, Genpril, Haltran, IBU, Ibuprin, Ibuprohm, Menadol, Midol IB, Motrin, Nuprin, Saleto)
  • Indomethacin (Indochron E-R, Indocin, Indocin SR, Indomethacin, Indomethacin SR, Novo-Methacin)
  • Ketoprofen (Actron, Orudis, Orudis KT, Oruvail)
  • Ketorolac tromethamine (Toradol)
  • Magnesium salicylate (Doan's, Magan, Mobidin, Backache Maximum Strength Relief, Bayer Select Maximum Strength Backache, Momentum Muscular Backache Formula, Nuprin Backache, Mobigesic, Magsal)
  • Meclofenamate sodium (Mecolfen, Meclomen)
  • Mefenamic acid (Ponstan, Ponstel)
  • Nabumetone (Relafen)
  • Naproxen (EC-Naprosyn, Napron X, Naprosyn)
  • Naproxen sodium (Aleve, Anaprox, Anaprox DS, Naprelan)
  • Oxaprozin (Daypro)
  • Piroxicam (Feldene)
  • Salsalate or salicylic acid (Amigesic, Argesic-SA, Arthra-G, Disalcid, Marthritic, Mono-Gesic, Salflex, Salgesic, Salsitab)
  • Sodium salicylate (Pabalate)
  • Sodium thiosalicylate (Rexolate)
  • Sulfasalazine (Azulfidine EN-tabs, Salazopyrin, SAS-500)
  • Sulindac (Clinoril)
  • Tolmetin sodium (Tolectin, Tolectin DS)
  • and others
Note : Besides reducing pain and inflammation, aspirin and, to a lesser extent, other NSAIDs interfere with cells in the blood called platelets, which facilitate clotting.

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