Oral Hypoglycemics

Vitamin B 12 —Supplementation Possibly Helpful Coenzyme Q 10 (CoQ 10 ) —Possible Benefits and Risks Ipriflavone —Might Require Reduction in Medication Dosage Magnesium —Might Require Reduction in Medication Dosage Herbs and Supplements —Might Require Reduction in Medication Dosage Potassium Citrate —Possible Harmful Interaction Ginkgo Biloba —Possible Harmful Interactions Dong Quai, St. John's Wort —Possible Harmful Interaction

These medications are used for controlling blood sugar in adult-onset diabetes.Drugs in this family include:

  • Acarbose (Prandase, Precose)
  • Acetohexamide (Dymelor)
  • Chlorpropamide (Diabinese)
  • Glimepiride (Amaryl)
  • Glipizide (Glucotrol, Glucotrol XL)
  • Glyburide or glibenclamide (DiaBeta, Glynase, Micronase)
  • Metformin (Glucophage)
  • Miglitol (Glyset)
  • Phenformin
  • Pioglitazone (Actos)
  • Rosiglitazone (Avandia)
  • Repaglinide (Prandin)
  • Tolazamide (Tolinase)
  • Tolbutamide (Orinase)
  • Troglitazone (Rezulin)
  • and others

Vitamin B 12 The biguanide oral hypoglycemic drugs, metformin and phenformin, can cause malabsorption of vitamin B 12 . 1 In turn, this can lead to vitamin B 12 deficiency. 11 Taking vitamin B 12 supplements should easily solve this problem.

Coenzyme Q 10 (CoQ 10 ) Studies suggest that the oral hypoglycemic drugs glyburide, phenformin, and tolazamide may inhibit the normal production of the substance coenzyme Q 10 (CoQ 10 ). 2 While there is as yet no direct evidence that taking extra CoQ 10 will provide any specific benefit, supplementing with CoQ 10 on general principle might make sense. In addition, there is some evidence that use of CoQ 10 could improve blood sugar control for people with diabetes. While this could be helpful, keep in mind that if it works, you might need to reduce your medication dosage. 6-7

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