Diagnosis of Hodgkins Disease
The doctor will ask about your symptoms and medical history. A physical exam will be done, paying careful attention to your lymph nodes. Most enlarged or swollen lymph nodes are caused by an infection, not lymphomas. If infection is suspected, you may be given an antibiotic medication and instructed to return for a follow up appointment. If swelling persists, a lymph node biopsy may be ordered.
Lymph Node BiopsyFor a lymph node biopsy, all or part of one of your lymph nodes will be removed. The tissue sample will be examined under a microscope. The biopsy can show whether there is cancer and the type and extent of cancer. A specific type of cell, called Reed-Sternberg cell, is associated with Hodgkins lymphoma.
Staging of Hodgkins DiseaseIf cancer is found, your prognosis and treatment depend on the location, size, and stage of the cancer, as well as your general health. Staging is an evaluation to determine whether the cancer has spread and, if it has, what body parts are affected.The following factors are used to determine the stage of Hodgkins disease:
- The number and location of lymph nodes affected
- Whether the affected lymph nodes are on one or both sides of the diaphragm. The diaphragm is the thin muscular sheet that separates the chest from the abdomen.
- Whether the disease has spread to other lymphatic tissues, such as the spleen
- Whether the disease has spread to the bone marrow, liver, or other places outside the lymphatic system
- Blood tests
- Imaging studies
- Additional biopsies of lymph nodes
- Biopsies of the liver, bone marrow, or other tissues
- Laparotomy—rarely done
- Stage I—cancer is found only in a single lymph node area, in the area immediately surrounding that node, or in a single organ
- Stage II—cancer involves more than one lymph node area on one side of the diaphragm
- Stage III—cancer involves lymph node regions above and below the diaphragm
- Stage IV—cancer involves one or more organs outside the lymph system or a single organ and a distant lymph node site
Casciato D. Manual of Clinical Oncology . 6th ed. Lippincott Williams & Williams; 2009
Hodgkin disease. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us. Updated March 8, 2013. Accessed April 30, 2013.
Hodgkin lymphoma. National Cancer Institutewebsite. Available at: http://www.cancer.gov/cancertopics/types/hodgkin. Accessed April 30, 2013.
- Reviewer: Mohei Abouzied, MD; Michael Woods, MD
- Review Date: 04/2013
- Update Date: 03/18/2013
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