Acute Interstitial Nephritis
DefinitionAcute interstitial nephritis is a kidney disorder that happens when the kidneys are unable to filter waste and fluid properly due to inflammation of the kidney.
|Anatomy of the Kidney|
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CausesAcute interstitial nephritis can be caused by:
- Certain medications
- Anti-ulcer drugs
- Nonsteroidal anti-inflammatory drugs
- Infections such as:
- Conditions that affect the immune system such as lupus
Risk FactorsRisk factors that increase your chance of developing acute interstitial nephritis include:
- In adults: drug or medication use
- In children: infection
- Decrease in urine output
- Blood in urine
- Side or loin pain
- Swelling of the body
- Nausea and vomiting
- Loss of appetite
- Aching joints
DiagnosisYour doctor will ask about your symptoms and medical history. A physical exam will be done. Tests may include:
TreatmentTalk with your doctor about the best treatment plan for you. You treatment will depend on the cause of your acute interstitial nephritis. Treatment options include the following:
MedicationsIf medications are the cause of your interstitial nephritis, your doctor may have you stop taking medications or prescribe a different one.Your doctor may prescribe the following:
- Antibiotics to treat infection
- Corticosteroid or cyclophosphamide to treat interstitial nephritis
DialysisSome people with interstitial nephritis need dialysis . During dialysis, a machine does the work of your kidneys by removing waste.
PreventionTo help reduce your chances of developing acute interstitial nephritis, your doctor may suggest you avoid certain medications such as penicillin or nonsteroidal anti-inflammatory drugs.
National Kidney Foundation
National Kidney and Urologic Diseases Information Clearinghouse
Kidney Foundation of Canada
Acute interstitial nephritis. DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us. Updated November 10, 2010. Accessed July 12, 2013.
Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial nephritis. Am Fam Physician. 2003 June 15;67(12):2527-2534. Available at: http://www.aafp.org/afp/20030615/2527.html. Accessed July 12, 2013.
Plakoglannis R, Nogid A: Acute interstitial nephritis associated with coadministration of vancomycin and ceftriaxone: case series and review of the literature. Pharmacotherapy. 2007:27:1456-1461.
Sierra F, Suzrez M, et al. Systematic review: Proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmaco Ther. 2007:26:545-553.
- Reviewer: Adrienne Carmack, MD; Michael Woods, MD
- Review Date: 07/2013
- Update Date: 05/11/2013
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