(Cervical Intraepithelial Neoplasia [CIN]; Precancerous Changes of the Cervix)
DefinitionDysplasia is abnormal growth or development of cells. Cervical dysplasia happens in the cells covering the surface of a woman's cervix. If cervical dysplasia is not treated, it may lead to cervical cancer .
|Female Reproductive Organs|
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CausesCervical dysplasia is caused by a sexually transmitted virus. The virus is called the human papillomavirus (HPV). This virus causes abnormal changes in the cells of the cervix. The most significant cervical change would be cancer. There are different types of HPV. The risk of cervical disease may be high or low depending on the type of HPV.
Risk FactorsFactors that increase your risk of cervical dysplasia include:
- Multiple sexual partners
- Early onset of sexual activity (before age 18)
- Early childbearing (before age 16)
- Sexually transmitted diseases
- Genital herpes
- Exposure to diethylstilbestrol (DES) in the womb—an estrogen-like substance given to prevent miscarriages in high-risk pregnancies
SymptomsThere are often no apparent symptoms with cervical dysplasia. Cervical changes are found through screening tests.
DiagnosisProcedures to detect cervical dysplasia include the following:
Pap TestRegular pap tests can help diagnose or monitor cervical dysplasia. Cells are collected from your cervix. They are sent to a lab for analysis. If abnormal cell growth is found, a colposcopy may be done.
HPV DNA AnalysisThis will test for both the presence and type of HPV in cervical tissues. The presence of abnormal cells and high-risk HPV DNA increases the risk of significant disease. In this case, more evaluation and treatment will be needed.
Colposcopy and BiopsyIf further evaluation of the cervix is necessary, then a colposcopy will be performed. During this procedure, the cervix is lightly coated with a vinegar solution. The solution will highlight abnormal cells. A magnifying scope is then used to examine the cervix. A biopsy will be done on any areas that show abnormal changes. A biopsy is the removal of tiny bits of tissue. A sample of the cells of the canal of the cervix will also be taken. This is done with a small brush. The biopsy and the sample of cells from the cervical canal will be sent to a lab for analysis. In the lab, abnormal cell growth will be classified as one of the following:
- Severe (carinoma-in-situ)
- Invasive cervical cancer
TreatmentTreatment depends on the severity of dysplasia, location, and size of the area of abnormal cells. Some cervical changes do not need treatment. They may be followed by periodic Pap tests to monitor for any further changes. Some types of dysplasia may disappear on its own. If dysplasia does not resolve on its own, these treatments options are available:
MedicationA topical medication that is used to treat cancer may be applied to your cervix. The medication will help stop the abnormal cells from growing.
Cone BiopsyThis biopsy is the removal of a tiny, cone-shaped piece of tissue. The sample is taken from the opening of the cervix and the cervical canal. The biopsy tissue will be analyzed. The results will show whether any of the abnormal cell growth is cancerous.
Loop Electrosurgical Excision Procedure (LEEP)A small biopsy of the cervix is taken with a wire loop heated by electric current. The results will show whether any of the abnormal cells are precancerous or cancerous.Note : Both cone biopsy and LEEP biopsy techniques remove all abnormal tissue. These procedures may be used for early, noninvasive cancer treatment and diagnosis.
CryosurgeryCryosurgery freezes and destroys the dysplasia on the cervix. This method is not recommended for treating large areas of dysplasia.
Laser TreatmentLaser treatment uses a concentrated, high-energy beam of light to destroy abnormal cells. This method is more favorable than cryosurgery. There is less destruction of surrounding normal tissue. Although, healing is faster than with other methods and laser treatment is expensive. It is not always available.
Cancer TreatmentCone biopsy and LEEP are usual cures for dysplasia. However, if the cone biopsy or LEEP biopsy shows invasive cancer, treatment methods may include:
Lifestyle ChangesTo reduce the risk of cervical dysplasia, take these steps:
- Use safe sex methods to prevent HPV infection.
- If you smoke, talk to your doctor about ways to quit .
- Get vaccinated against HPV infection. The HPV vaccine called Gardasil is approved for use in females aged 9-26 years old. The HPV vaccine called Cervarix is approved for females aged 10-25 years old.
- If you are age 21-29 years, you should have the Pap test every 2 to 3 years.
- If you are age 30-65, you should have the Pap test along with the HPV test every 3 to 5 years.
- If you are age 65 or older, you may be able to stop having Pap and HPV tests if you have had normal results (such as, 3 normal results in a row and no abnormal results in the past 10 years).
- Note: You will need to have Pap tests done more often if you have abnormal results. You may also need more frequent testing if you have certain conditions, like a suppressed immune system or a history of cervical dysplasia or cervical cancer. Talk to your doctor about the right screening schedule for you.
American Congress of Obstetricians and Gynecologists
American Sexual Health Association
The Society of Obstetricians and Gynaecologists of Canada
Women's Health Matters
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3/19/2012 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Screening for cervical cancer. US Preventive Services Task Force website. Available at:http://www.uspreventiveservicestaskforce.org/uspstf/uspscerv.htm. Published March 2012. Accessed March 19, 2012.
6/17/2014 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Rahangdale L, Lippmann QK, et al. Topical 5-fluorouracil for treatment of cervical intraepithelial neoplasia 2: a randomized controlled trial. Am J Obstet Gynecol. 2014 Apr;210(4):314.e1-8.
- Reviewer: Andrea Chisholm, MD
- Review Date: 12/2014
- Update Date: 12/20/2014
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