Cushing's Syndrome

(Cushing's Disease; Hypercortisolism)

Definition

Cushing's syndrome is a hormone disorder. Cortisol, in normal doses, helps the body manage stress and infection. However, these high levels over a long period of time can cause several health problems.

Causes

Cushing's syndrome is caused by extended exposure to a hormone called cortisol. Prolonged or excess exposure to cortisol may be caused by:
  • Long-term use of corticosteroid hormones such as cortisone or prednisone
  • Excess production of cortisol by:
    • Tumor or abnormality of the adrenal gland.
    • Tumor or abnormality of the pituitary gland. In the case of a pituitary tumor, it is called Cushing's disease
    • Rarely, tumors of the lungs, thyroid, kidney, pancreas, or thymus gland.
Pituitary and Adrenal Glands
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Risk Factors

Factors that may increase your chance of Cushing's syndrome include:

Symptoms

Cushing's syndrome may cause:
  • Weight gain of the upper body and trunk
  • Rounded face
  • Severe fatigue or muscle weakness
  • Easily bruised, thinner skin
  • Purple stretch marks
  • Excess hair growth or acne in women
  • Menstrual disorders, especially infrequent or absent periods
  • Reduced fertility and interest in sex
  • Personality changes or mood swings

Diagnosis

You will be asked about your symptoms and medical history. A physical exam will be done. Tests may be done to determine the level of cortisol and find a cause.Tests for cortisol levels may include:
  • 24-hour urinary free cortisol level
  • Late-evening cortisol saliva/blood level
  • Dexamethasone suppression test
Tests to determine the cause of Cushing's Syndrome may include:
  • Blood test for adrenocorticotropin hormone (ACTH) level
  • High-dose dexamethasone suppression test
Other tests may help to see if there is a tumor on the pituitary or adrenal glands. Images may be taken with:

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Treatment

Treatment of Cushing's syndrome depends on the cause. Talk with your doctor about the best treatment plan for you. Options include:
  • Surgical removal of tumor
  • Surgical removal of part, all, or both adrenal glands
  • Radiation therapy for some persistent tumors
  • Gradual withdrawal of cortisone-type drugs under close medical supervision
  • Drugs that decrease cortisol production or block the functioning of other adrenal products

Prevention

Work with your doctor to keep your use of corticosteroid drugs to a minimum.

RESOURCES

Cushing's Support and Research Foundation
http://www.CSRF.net

Family Doctor—American Academy of Family Physicians
http://familydoctor.org

CANADIAN RESOURCES

Health Canada
http://www.hc-sc.gc.ca

The College of Family Physicians of Canada
http://www.cfpc.ca

References

Arnaldi G, Angeli A, et al. Diagnosis and complications of Cushing’s syndrome: a consensus statement. J Clin Endocrinolo Metabo. 2003;88:5593-5602.

Cushing disease. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed . Updated February 21, 2014. Accessed February 27, 2014.

Cushing's syndrome. National Endocrine and Metabolic Diseases Information Service website. Available at: http://endocrine.niddk.nih.gov/pubs/cushings/cushings.aspx. Updated April 6, 2012. Accessed February 27, 2014.

Diez JJ, Iglesias P. Pharmacological therapy of Cushing’s syndrome: drugs and indications. Mini Rev Med Chem. 2007;7(5):467-480.

Kirk LF Jr, Hash RB, et al. Cushing's disease: clinical manifestations and diagnostic evaluation. Am Fam Physician. 2000;62(5):1119-1127, 1133-1134.

Tritos NA, Biller BM, et al. Management of Cushing disease. Nat Rev Endocrinol. 2011;7(5):279-289.

Makras P, Toloumis G, et al. The diagnosis and differential diagnosis of endogenous Cushing’s syndrome. Hormones. 2006;5:231-250.

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