DefinitionMiscarriage refers to the premature end of a pregnancy before the developing baby is able to survive outside the uterus. Miscarriage can occur during the first or second trimester, before 20 weeks. Most occur in the first 12 weeks of pregnancy. They often are unexpected and isolated events. About 15%-20% of recognized pregnancies end this way.
|Fetus in First Trimester|
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CausesMiscarriages often occur for the following reasons:
- Chromosomal abnormalities (common cause)
- Abnormalities in the uterine tract, such as fibroids
- Hormonal problems, such as not having enough progesterone, a female hormone needed to support pregnancy
- Factors related to the immune system, such as blood-clotting problems or rejection of the fetus
Risk FactorsMiscarriages are more common in women 35 years and older. Other factors that may increase your chance of having a miscarriage include:
- Smoking , drinking alcohol , or using drugs during pregnancy
- Certain medications
- Exposure to certain environmental toxins
- Autoimmune disorders, such as systemic lupus erythematosus
- High-dose radiation therapy on the ovaries, uterus, or the pituitary gland during treatment of childhood cancers
- High blood pressure during pregnancy— pre-eclampsia
- Threatened miscarriage
- Induced labor
- Preterm delivery
- Low birth weight
- Postpartum hemorrhage
SymptomsMiscarriage may cause:
- Vaginal bleeding
- Pink or brown discharge
- Passing the fetus, placenta, and surrounding membranes through the vagina
Recurrent MiscarriageWhile miscarriage usually is a one-time occurrence, up to 1 in 20 couples experience two miscarriages in a row, and 1 in 100 have three or more.In some cases, these couples have an underlying problem. Couples who have experienced two or more miscarriages should have a complete medical evaluation to learn the cause and how they can prevent another one from occurring.Cause of repeat miscarriages may include:
- Chromosome problem in one member of the couple
- Uterine abnormalities
- Hormone problems
- Immune system problems
- Unknown causes
DiagnosisYou will be asked about your symptoms, the length of your pregnancy, and when you first noticed a change in your condition. The doctor will perform physical and pelvic exams.Prior to miscarriage, tests may include:
- Ultrasound —to assess the health of the fetus
- Blood tests—to check the exact amount of the hormone (called human chorionic gonadotropin or hCG) important to sustain an early pregnancy
- Examination of the tissue that has passed through the vagina
- Blood tests—to check for a chromosomal error in the man or the woman or to check hormone and antibody levels
- Endometrial biopsy —to check the uterine lining to see if it can support a pregnancy
TreatmentImmediate care usually involves observation only, especially in early or first trimester miscarriages. Medication may be indicated in the event of heavy bleeding or cramping.A dilation and evacuation (D&E) may be needed if uterine contents are not spontaneously passed through the vagina. During a D&E, the doctor dilates the cervix, inserts a tool into the uterus, and suctions out remaining material.
Support ServicesTo help you deal with your loss, the doctor may refer you to a counselor. You may also benefit from participating in a support group .
PreventionBefore you start to plan your next pregnancy consider the following regarding your health:
- Is your diet ready to support another pregnancy?
- Are there habits you should change prior to another pregnancy?
- What medications are you taking and will they affect a pregnancy?
- How is your health?
- Are there issues you should resolve before trying another pregnancy?
- Medications such as
- Antibiotics to treat related infections
- Hormone (progesterone) supplements
- Aspirin and other medications to treat blood-clotting problems
- Surgery for uterine problems such as:
- Uterine fibroids
- Septate uterus (tissue in the center of the uterus)
- Incompetent (weakened) cervix
The American Congress of Obstetricians and Gynecologists
March of Dimes
The Society of Obstetricians and Gynaecologists of Canada
Women's Health Matters
First trimester pregnancy loss. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated October 25, 2013. Accessed August 19, 2014.
Miscarriage. American Pregnancy Association website. Available at: http://americanpregnancy.org/pregnancycomplications/miscarriage.html. Updated June 2014. Accessed August 19, 2014.
Miscarriage. March of Dimes website. Available at: http://www.marchofdimes.com/loss/miscarriage.aspx. Updated July 2012. Accessed August 19, 2014.
Second trimester pregnancy loss. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated February 28, 2014. Accessed August 19, 2014.
Recurrent pregnancy loss. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated August 11, 2014. Accessed August 19, 2014.
12/2/2008 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Winther JF, Boice JD Jr, Svendsen AL, Frederiksen K, Stovall M, Olsen JH. Spontaneous abortion in a Danish population-based cohort of childhood cancer survivors. J Clin Oncol. 2008;26:4340-4346.
4/16/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Bhattacharya S, Townend J, Shetty A, Campbell D, Bhattacharya S. Does miscarriage in an initial pregnancy lead to adverse obstetric and perinatal outcomes in the next continuing pregnancy? BJOG. 2008;115:1623-1629.
6/25/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Nakhai-Pour HR, Broy P, Bérard A. Use of antidepressants during pregnancy and the risk of spontaneous abortion. CMAJ. 2010 May 31.
- Reviewer: Andrea Chisholm, MD
- Review Date: 08/2014
- Update Date: 09/30/2013
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