Morton's Neuroma

(Interdigital Neuroma; Intermetatarsal Neuroma)


Morton's neuroma is painful thickening of the tissue around one of the nerves in the foot. It can affect any of the toes in the foot. However, it most often affects the nerves that run between the third and fourth, or second and third toes.
Nerves of the Foot
Foot Anatomy Nerve and muscle
Copyright © Nucleus Medical Media, Inc.


The thickening of the nerve caused by inflammation and the build up of fibrous tissue on the nerve's outer coating. This fibrous build-up is a reaction to the irritation resulting from nearby bones and ligaments rubbing against the nerves.Irritation can be caused by:
  • Wearing shoes that are too tight
  • Wearing shoes that place the foot in an awkward position, such as with high heels
  • A foot that is mechanically unstable
  • Repetitive trauma to the foot such as from sports activities like tennis, basketball, and running
  • Trauma to the foot caused by an injury such as a sprain or fracture
It is unusual for more than one Morton's neuroma to occur on one foot at the same time. It is rare for Morton's neuroma to occur on both feet at the same time.

Risk Factors

Morton's neuroma is more common in women. Other factors that may increase your chance of Morton's neuroma include:
  • Wearing narrow and/or high-heeled shoes
  • Obesity
  • Injuries to the foot
  • Activities that cause repetitive trauma to the foot such as sports-related activities


Morton's neuroma may cause:
  • Burning, pain, tingling, and numbness often shooting into the toes
  • Discomfort that is worse while walking
  • Feeling of a lump between the toes
  • Symptoms are usually temporarily relieved when:
    • Taking off the shoes
    • Flexing the toes
    • Rubbing the feet

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