Peptic Ulcer

(PUD; Duodenal Ulcer; Ulcer, Peptic; Ulcer, Duodenal)

Definition

A peptic ulcer is a sore in the lining of the stomach or the first part of the small intestine. This area of the small intestine is called the duodenum. Peptic ulcers may be named by their location:
Gastric Ulcer
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Causes

Upsets in the balance of stomach acid and digestive juices can lead to an ulcer. This can be caused by:
  • Helicobacter pylori ( H. pylori ) infection
  • Use of nonsteroidal anti-inflammatory drugs (NSAIDs)
Less common causes include:

Risk Factors

Factors that may increase your chance of peptic ulcer include:
  • H. pylori infection
  • Taking NSAIDs for a long time and at higher doses
  • Prior peptic ulcer disease
  • Cigarette smoking
  • Alcohol use disorder

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