Autoimmune Hemolytic Anemia
DefinitionAnemia is a low level of healthy red blood cells (RBC). RBCs carry oxygen from the lungs to the rest of the body. When red blood cells are low, the body does not get enough oxygen. This can cause symptoms such as fatigue, pale skin, or irregular heartbeat.Autoimmune hemolytic anemia is caused by the destruction of RBCs. It can be a serious, fatal condition that requires care from a doctor.
|Red Blood Cells|
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CausesThis type of anemia is caused by an autoimmune problem. The immune system attacks and destroys red blood cells. The abnormal reaction of the immune system may be caused by:
- Certain medications
- Collagen-vascular (autoimmune) diseases such as lupus
Risk FactorsFactors that may increase your risk of developing autoimmune hemolytic anemia include:
- Recent viral infections
- Taking medications that can cause autoimmune hemolytic anemia
- Cancer or leukemia
- Collagen-vascular (autoimmune) disease
- Family history of hemolytic disease
SymptomsSymptoms may include:
- Dark brown urine
- Yellow or pale skin
- Muscle pains
- Nausea and vomiting
- Shortness of breath
- Rapid heartbeat
DiagnosisYour doctor will ask about your symptoms, medications, and medical history. A physical exam will be done. You may be referred to a hematologist who is a doctor who specializes in blood and blood-forming tissues. Your bodiliy fluids may be tested. This can be done with:
- Blood tests
- Urine tests
TreatmentTalk with your doctor about the best treatment plan for you. Mild cases may not need treatment. They may resolve on their own. Treatment options include the following:
Treating the Underlying ConditionTreating the cause of autoimmune hemolytic anemia may help treat the condition. Causes include cancer, medications, or collagen-vascular disease.
CorticosteroidsCortisone-like drugs suppress the immune response. These drugs usually improve the more common types of autoimmune hemolytic anemia.
Other Immunosuppressive DrugsOther drugs that suppress the immune system may be used if corticosteroids are not effective.
TransfusionYou will need transfusions if your blood gets too anemic.
PreventionIt is not possible to prevent autoimmune hemolytic anemia. It has multiple causes.
Family Doctor—American Academy of Family Physicians
National Organization for Rare Disorders, Inc.
Canadian Family Physician
Canadian Organization for Rare Disorders
Autoimmune hemolytic anemia. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated December 2, 2013. Accessed August 28, 2014.
Dhaliwal G, Cornett PA, Tierney LM Jr. Hemolytic anemia. Am Fam Physician. 2004;69:2599-2606.
Lechner K, Jäger U. How I treat autoimmune hemolytic anemias in adults. Blood. 2010 Sep 16;116(11):1831-8.
- Reviewer: Marcin Chwistek, MD
- Review Date: 08/2014
- Update Date: 08/28/2014
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