Erythema Nodosum


Erythema nodosum is the name given to tender lumps on the legs and sometimes the arms. They are caused by inflammation of the fat or connective tissue beneath the skin.
Erythema Nodosum
Erythema  Nodusum
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Erythema nodosum is thought to be a type of autoimmune reaction. It may be caused by:
  • Infections from a:
    • Virus
    • Bacteria, especially strep throat
    • Fungus
  • Inflammatory conditions:
  • Medications:
    • Sulfa drugs and some other antibiotics
    • Iodides
    • Bromides
    • Birth control pills
    • Leukotriene modifiers
    • Proton pump inhibitors
  • Certain types of cancer:
    • Lymphoma
    • Leukemia
Sometimes the cause of erythema nodosum is not known.

Risk Factors

This condition is rare. It is more common in females and young adults aged 20-30 years old. Having any of the causes listed above will only slightly increase your risk of the disorder.


Symptoms include:
  • Very tender, deep lumps, like bruises, that change color in the same way, from pink to blue to brown:
    • Usually located on your shins
    • May also appear on the forearms, trunk, neck, and head
  • Associated joint pain and fever and redness around the eyes

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