DefinitionErythema nodosum is the name given to extremely tender lumps on the legs and sometimes the arms. They are caused by inflammation of the fat or connective tissue beneath the skin. The bumps look like bruises. They change color in the same way, from pink to blue to brown.
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CausesErythema nodosum is thought to be a type of autoimmune reaction. It may be caused by:
- Infections from a:
- Inflammatory conditions
- Sulfa drugs and some other antibiotics
- Birth control pills
- Leukotriene modifiers
- Proton pump inhibitors
Risk FactorsThis condition is rare. It is more common in females and young adults aged 20-30 years old. Having any of the causes listed above will only slightly increase your risk of the disorder.The risk factor for erythema nodosum is genetics.
- Very tender, deep lumps, like bruises,
- Usually located on your shins
- May also appear on the forearms, trunk, neck, and head
- Associated joint pain and fever and redness around the eyes
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