Born into a distinguished family in Aachen (then ruled by Prussia but formerly Aix-la-Chapelle, France), Frances ran the household after her mothers death and established a reputation for generosity to the poor. In 1844 she became a Secular Franciscan. The next year she and four companions established a religious community devoted to caring for the poor. In 1851 the Sisters of the Poor of St. Francis (a variant of the original name) were approved by the local bishop; the community soon spread. The first U.S. foundation was made in 1858.
Mother Frances visited the United States in 1863 and helped her sisters nurse soldiers wounded in the Civil War. She visited the United States again in 1868. When Philip Hoever was establishing the Brothers of the Poor of St. Francis, she encouraged him.
When Mother Frances died, there were 2,500 members of her community worldwide. The number has kept growing. They are still engaged in operating hospitals and homes for the aged. Mother Mary Frances was beatified in 1974.