When she was 32 she met St. Francis de Sales, who became her spiritual director, softening some of the severities imposed by her former director. She wanted to become a nun but he persuaded her to defer this decision. She took a vow to remain unmarried and to obey her director.
After three years Francis told her of his plan to found an institute of women which would be a haven for those whose health, age or other considerations barred them from entering the already established communities. There would be no cloister, and they would be free to undertake spiritual and corporal works of mercy. They were primarily intended to exemplify the virtues of Mary at the Visitation (hence their name, the Visitation nuns): humility and meekness.
The usual opposition to women in active ministry arose and Francis de Sales was obliged to make it a cloistered community following the Rule of St. Augustine. Francis wrote his famous Treatise on the Love of God for them. The congregation (three women) began when Jane Frances was 45. She underwent great sufferings: Francis de Sales died; her son was killed; a plague ravaged France; her daughter-in-law and son-in-law died. She encouraged the local authorities to make great efforts for the victims of the plague and she put all her convents resources at the disposal of the sick.
During a part of her religious life she had to undergo great trials of the spiritinterior anguish, darkness and spiritual dryness. She died while on a visitation of convents of the community.