Born in Nisibis, Mesopotamia, he was baptized as a young man and became famous as a teacher in his native city. When the Christian emperor had to cede Nisibis to the Persians, Ephrem, along with many Christians, fled as a refugee to Edessa. He is credited with attracting great glory to the biblical school there. He was ordained a deacon but declined becoming a priest (and was said to have avoided episcopal consecration by feigning madness!).
He had a prolific pen and his writings best illumine his holiness. Although he was not a man of great scholarship, his works reflect deep insight and knowledge of the Scriptures. In writing about the mysteries of humanitys redemption, Ephrem reveals a realistic and humanly sympathetic spirit and a great devotion to the humanity of Jesus. It is said that his poetic account of the Last Judgment inspired Dante.
It is surprising to read that he wrote hymns against the heretics of his day. He would take the popular songs of the heretical groups and, using their melodies, compose beautiful hymns embodying orthodox doctrine. Ephrem became one of the first to introduce song into the Churchs public worship as a means of instruction for the faithful. His many hymns have earned him the title Harp of the Holy Spirit.
He preferred a simple, austere life, living in a small cave overlooking the city of Edessa. It was here he died around 373.