Claude showed remarkable preaching skills long before his ordination in 1675. Two months later he was made superior of a small Jesuit residence in Burgundy. It was there he first encountered Margaret Mary Alacoque. For many years after he served as her confessor.
He was next sent to England to serve as confessor to the Duchess of York. He preached by both words and by the example of his holy life, converting a number of Protestants. Tensions arose against Catholics and Claude, rumored to be part of a plot against the king, was imprisoned. He was ultimately banished, but by then his health had been ruined.
He died in 1682. Pope John Paul the Second canonized Claude la Colombière in 1992.