Already a fine student, he soon gained a reputation in his religious community as a "walking dictionary" who quickly grasped Scripture and theology. For some time he was tormented by scruples, but they reportedly left him at the very hour he celebrated his first Mass. From that day, serenity penetrated his very being.
In 1621, at age 29, Anthony was struck by lightning while praying in the church of the Holy House at Loreto. He was carried paralyzed from the church, expecting to die. When he recovered in a few days he realized that he had been cured of acute indigestion. His scorched clothes were donated to the Loreto church as an offering of thanks for his new gift of life.
More important, Anthony now felt that his life belonged entirely to God. Each year thereafter he made a pilgrimage to Loreto to express his thanks.
He also began hearing confessions, and came to be regarded as an outstanding confessor. Simple and direct, he listened carefully to penitents, said a few words and gave a penance and absolution, frequently drawing on his gift of reading consciences.
In 1635 he was elected superior of the Fermo Oratory. He was so well regarded that he was reelected every three years until his death. He was a quiet person and a gentle superior who did not know how to be severe. At the same time he kept the Oratorian constitutions literally, encouraging the community to do likewise.
He refused social or civic commitments and instead would go out day or night to visit the sick or dying or anyone else needing his services. As he grew older, he had a God-given awareness of the future, a gift which he frequently used to warn or to console.
But age brought its challenges as well. He suffered the humility of having to give up his physical faculties one by one. First was his preaching, necessitated after he lost his teeth. Then he could no longer hear confessions. Finally, after a fall, he was confined to his room. The archbishop himself came each day to give him holy Communion. One of Anthonys final acts was to reconcile two fiercely quarreling brothers.