Angeline was born to the Duke of Marsciano (near Orvieto). She was 12 when her mother died. Three years later the young woman made a vow of perpetual chastity. That same year, however, she yielded to her fathers decision that she marry the Duke of Civitella. Her husband agreed to respect her previous vow.
When he died two years later, Angeline joined the Secular Franciscans and with several other women dedicated herself to caring for the sick, the poor, widows and orphans. When many other young women were attracted to Angelines community, some people accused her of condemning the married vocation. Legend has it that when she came before the King of Naples to answer these charges, she had burning coals hidden in the folds of her cloak. When she proclaimed her innocence and showed the king that these coals had not harmed her, he dropped the case.
Angeline and her companions later went to Foligno, where her community of Third Order sisters received papal approval in 1397. She soon established 15 similar communities of women in other Italian cities.
Angeline died on July 14, 1435, and was beatified in 1825.