City of Brass

City of Brass


The Harappa Ancestry Project

posted by Aziz Poonawalla

This is a guest post by Zack Ajmal.

It all started DNA Day 2010 when Razib tweeted about a $99 sale for the DNA test at23andme. I ordered one immediately. Over the next few months, a lot of my free time was spent poring over and analyzing my genomic results.

While the health and physical traits information was interesting, I found the ancestry information that can be deduced from your genome to be fascinating. That might be because I was working on collecting together and digitizing our family tree at the time. Trying to figure out which ancestral groups you are descended from and how different ancestral groups admixed together is a fun application of genome analysis. Using the DNA information together with genealogical records can provide more clues to your ancestry than each would by itself.

With several genome databases (HapMap, HGDP, etc) and software (like plink, admixture, Structure) publicly available, the days of the genome bloggers are here. And I am trying to be the latest one.

In starting this project, I have been inspired by the Dodecad Ancestry Project by Dienekes Pontikos andEurogenes Ancestry Project by David Wesolowski. The catalyst for this project was my friend Razib who I bug whenever I need to talk genetics.

South Asia is a huge region with more than 1.5 billion people and a lot of diversity. Current public genome databases do not have a lot of samples from South Asia. Also, a number of samples that do exist are from small, isolated groups like the Kalash or Burusho. Being of South Asian descent, I thought that it would be good to analyze genome data from different South Asian groups for a better understanding of our ancestry. Thus was born the Harappa Ancestry Project. I named it after Harappa, an archaeological site of the Indus Valley Civilization in Punjab, Pakistan.

People of South Asian origin, or from neighboring countries, are eligible to participate in this project. The list of countries of origin I am accepting are as follows:

  • Afghanistan
  • Bangladesh
  • Bhutan
  • Burma
  • India
  • Iran
  • Maldives
  • Nepal
  • Pakistan
  • Sri Lanka
  • Tibet

 

Right now, I am only accepting raw data samples from people who have tested with 23andme.

If you would like to participate, please send your All DNA raw data text file (zipped is better) downloaded from 23andme to harappa@zackvision.com along with ancestral background information about you and all four of your grandparents. Background information would include where they were born, mother tongue, caste/community to which they belonged, etc. Please provide as much ancestry information as possible and try to be specific. Do especially include information about any ancestry from outside South Asia. Please do not send data from close relatives.

Privacy is an important concern in these matters. Rest assured that the raw genetic data and ancestry information that you send me will not be shared with anyone. Your data will be used only for ancestry analysis. No analysis of physical or health/medical traits will be performed. The individual ancestry analysis published on my blog will be done using an ID of the form HRPnnnn known to only you and me.

I have received a number of samples and am working on admixture analysis right now. I hope to report my results on the Harappa Ancestry Project website soon.

Zack Ajmal is an Electrical Engineer, Dad, gadget-freak, bookworm, political animal, and global nomad. He lives in Atlanta, GA and dreams of traveling the world with his 6 year old daughter. He blogs (or rather procrastinates about blogging) at Procrastination.



  • Rick

    EUROPEAN LIFE DIED IN AUSCHWITZ
    The following is a copy of an article written by Spanish writer Sebastian Vilar Rodrigez and published in a Spanish newspaper on Jan. 15, 2008. It doesn’t take much imagination to extrapolate the message to the rest of Europe – and possibly to the rest of the world.
    REMEMBER AS YOU READ – THIS WAS IN A SPANISH NEWSPAPER
    Date: Tue. 15 January 2008 14:30
    ALL EUROPEAN LIFE DIED IN AUSCHWITZ
    By Sebastian Vilar Rodrigez
    I walked down the street in Barcelona, and suddenly discovered a terrible truth – Europe died in Auschwitz. We killed six million Jews and replaced them with 20 million Muslims. In Auschwitz we burned a culture, thought, creativity, and talent. We destroyed the Chosen People, truly chosen, because they produced great and wonderful people who changed the world.
    The contribution of this people is felt in all areas of life: science, art, international trade, and above all, as the conscience of the world.
    These are the people we burned.
    And under the pretense of tolerance, and because we wanted to prove to ourselves that we were cured of the disease of racism, we opened our gates to 20 million Muslims, who brought us stupidity and ignorance, religious extremism, and lack of tolerance, crime, and poverty, due to an unwillingness to work and support their families with pride.
    They have blown up our trains and turned our beautiful Spanish cities into the third world, drowning in filth and crime. Shut up in the apartments they receive free from the government, they plan the murder and destruction of their naive hosts.
    And thus, in our misery, we have exchanged culture for fanatical hatred, creative skill for destructive skill, intelligence for backwardness and superstition.
    We have exchanged the pursuit of peace of the Jews of Europe and their talent for a better future for their children, their determined clinging to life because life is holy, for those who pursue death, for people consumed by the desire for death for themselves and others, for our children and theirs.
    What a terrible mistake was made by miserable Europe.
    ***
    A lot of Americans have become so insulated from reality that they imagine America can suffer defeat without any inconvenience to them.
    Absolutely No Profiling! Pause a moment, reflect back, and take the following multiple choice test.
    These events are actual events from history. They really happened! Do you remember?
    HERE’S THE TEST
    1968, Bobby Kennedy was shot and killed by:
    Superman
    Jay Leno
    Harry Potter
    A Muslim male extremist between the ages of 17 and 40
    In 1972 at the Munich Olympics, athletes were kidnapped and massacred by:
    Olga Corbett
    Sitting Bull
    Arnold Schwarzenegger
    Muslim male extremists mostly between the ages of 17 and 40
    In 1979, the U.S. embassy in Iran was taken over by:
    Lost Norwegians
    Elvis
    A tour bus full of 80-year-old women
    Muslim male extremists mostly between the ages of 17 and 40
    During the 1980s a number of Americans were kidnapped in Lebanon by:
    John Dillinger
    The King of Sweden
    The Boy Scouts
    Muslim male extremists mostly between the ages of 17 and 40
    In 1983 the U.S. Marine barracks in Beirut was blown up by:
    A pizza delivery boy
    Pee Wee Herman
    Geraldo Rivera
    Muslim male extremists mostly between the ages of 17 and 40
    In 1985 the cruise ship Achille Lauro was hijacked and a 70-year-old American passenger was murdered and thrown overboard in his wheelchair by:
    The Smurfs
    Davey Jones
    The Little Mermaid
    Muslim male extremists mostly between the ages of 17 and 40
    In 1985 TWA flight 847 was hijacked at Athens and a U.S. Navy diver trying to rescue passengers was murdered by:
    Captain Kidd
    Charles Lindberg
    Mother Teresa
    Muslim male extremists mostly between the ages of 17 and 40
    In 1988, Pan Am Flight 103 was bombed by:
    Scooby Doo
    The Tooth Fairy
    The Sundance Kid
    Muslim male extremists mostly between the ages of 17 and 40
    In 1993 the World Trade Center was bombed the first time by:
    Richard Simmons
    Grandma Moses
    Michael Jordan
    Muslim male extremists mostly between the ages of 17 and 40
    In 1998 the U.S. embassies in Kenya and Tanzania were bombed by:
    Mr. Rogers
    Hillary Clinton, to distract attention from Wild Bill’s women problems
    The World Wrestling Federation
    Muslim male extremists mostly between the ages of 17 and 40
    On 9/11/01, four airliners were hijacked. Two were used as missiles to take out the World Trade Center. Of the remaining two, one crashed into the U.S. Pentagon and the other was diverted and crashed by the passengers. Thousands of people were killed by:
    Bugs Bunny, Wiley E. Coyote, Daffy Duck and Elmer Fudd
    The Supreme Court of Florida
    Mr Bean
    Muslim male extremists mostly between the ages of 17 and 40
    In 2002 the United States fought a war in Afghanistan against:
    Enron
    The Lutheran Church
    The NFL
    Muslim male extremists mostly between the ages of 17 and 40
    In 2002 reporter Daniel Pearl was kidnapped and murdered by:
    Bonnie and Clyde
    Captain Kangaroo
    Billy Graham
    Muslim male extremists mostly between the ages of 17 and 40
    And now we can add: In 2009, 31 people wounded and 13 American Soldiers murdered on base at Fort Hood by a Major who was known as…You guessed it – A Muslim male extremist between the age of 17 and 40.
    No, I really don’t see a pattern here to justify profiling. Do you? So, to ensure we Americans/Canadians never offend anyone, particularly fanatics intent on killing us, airport security screeners will no longer be allowed to profile certain people. They must conduct random searches of 80-year-old women, little kids, airline pilots with proper identification, secret agents who are members of the President’s security detail, 85-year old Congressmen with metal hips, and Medal of Honor winner and former Governor Joe Foss, but leave Muslim males between the ages 17 and 40 alone lest they be guilty of profiling.
    Let’s send this to as many people as we can so that the Nancy Pelosis, Gloria Aldreds, and other dunder-headed attorneys, along with Federal Justices who want to thwart common sense, feel ashamed of themselves – if they have any such sense.
    We can not allow the socialist transformation being brought on by the current administration to continue. Look at what it has done to Europe.
    We all must stand together before it’s too late and everything America stands for is lost.
    The Global Islamic population is approximately 1,200,000,000. That is ONE BILLION TWO HUNDRED MILLION, or 20% of the world’s population.
    They have received the following Nobel Prizes:
    Literature:
    1988 – Najib Mahfooz
    Peace:
    1978 – Mohamed Anwar El-Sadat
    1990 – Elias James Corey
    1994 – Yaser Arafat:
    1999 – Ahmed Zewai
    Economics:
    (zero)
    Physics:
    (zero)
    Medicine:
    1960 – Peter Brian Medawar
    1998 – Ferid Mourad
    TOTAL: 7 SEVEN
    The Global Jewish population is approximately 14,000,000. That is FOURTEEN MILLION, or about 0.02% of the world’s population.
    They have received the following Nobel Prizes:
    Literature:
    1910 – Paul Heyse
    1927 – Henri Bergson
    1958 – Boris Pasternak
    1966 – Shmuel Yosef Agnon
    1966 – Nelly Sachs
    1976 – Saul Bellow
    1978 – Isaac Bashevis Singer
    1981 – Elias Canetti
    1987 – Joseph Brodsky
    1991 – Nadine Gordimer World
    Peace:
    1911 – Alfred Fried
    1911 – Tobias Michael Carel Asser
    1968 – Rene Cassin
    1973 – Henry Kissinger
    1978 – Menachem Begin
    1986 – Elie Wiesel
    1994 – Shimon Peres
    1994 – Yitzhak Rabin
    Physics:
    1905 – Adolph Von Baeyer
    1906 – Henri Moissan
    1907 – Albert Abraham Michelson
    1908 – Gabriel Lippmann
    1910 – Otto Wallach
    1915 – Richard Willstaetter
    1918 – Fritz Haber
    1921 – Albert Einstein
    1922 – Niels Bohr
    1925 – James Franck
    1925 – Gustav Hertz
    1943 – Gustav Stern
    1943 – George Charles de Hevesy
    1944 – Isidor Issac Rabi
    1952 – Felix Bloch
    1954 – Max Born
    1958 – Igor Tamm
    1959 – Emilio Segre
    1960 – Donald Glaser
    1961 – Robert Hofstadter
    1961 – Melvin Calvin
    1962 – Lev Davidovich Landau
    1962 – Max Ferdinand Perutz
    1965 – Richard Phillips Feynman
    1965 – Julian Schwinger
    1969 – Murray Gell-Mann
    1971 – Dennis Gabor
    1972 – William Howard Stein
    1973 – Brian David Josephson
    1975 – Benjamin Mottleson
    1976 – Burton Richter
    1977 – Ilya Prigogine
    1978 – Arno Allan Penzias
    1978 – Peter L Kapitza
    1979 – Stephen Weinberg
    1979 – Sheldon Glashow
    1979 – Herbert Charles Brown
    1980 – Paul Berg
    1980 – Walter Gilbert
    1981 – Roald Hoffmann
    1982 – Aaron Klug
    1985 – Albert Hauptman
    1985 – Jerome Karle
    1986 – Dudley R. Herschbach
    1988 – Robert Huber
    1988 – Leon Lederman
    1988 – Melvin Schwartz
    1988 – Jack Steinberger
    1989 – Sidney Altman
    1990 – Jerome Friedman
    1992 – Rudolph Marcus
    1995 – Martin Perl
    2000 – Alan J. Heeger
    Economics:
    1970 – Paul Anthony Samuelson
    1971 – Simon Kuznets
    1972 – Kenneth Joseph Arrow
    1975 – Leonid Kantorovich
    1976 – Milton Friedman
    1978 – Herbert Simon
    1980 – Lawrence Robert Klein
    1985 – Franco Modigliani
    1987 – Robert M. Solow
    1990 – Harry Markowitz
    1990 – Merton Miller
    1992 – Gary Becker
    1993 – Robert Fogel
    Medicine:
    1908 – Elie Metchnikoff
    1908 – Paul Erlich
    1914 – Robert Barany
    1922 – Otto Meyerhof
    1930 – Karl Landsteiner
    1931 – Otto Warburg
    1936 – Otto Loewi
    1944 – Joseph Erlanger
    1944 – Herbert Spencer Gasser
    1945 – Ernst Boris Chain
    1946 – Hermann Joseph Muller
    1950 – Tadeus Reichstein
    1952 – Selman Abraham Waksman
    1953 – Hans Krebs
    1953 – Fritz Albert Lipmann
    1958 – Joshua Lederberg
    1959 – Arthur Kornberg
    1964 – Konrad Bloch
    1965 – Francois Jacob
    1965 – Andre Lwoff
    1967 – George Wald
    1968 – Marshall W. Nirenberg
    1969 – Salvador Luria
    1970 – Julius Axelrod
    1970 – Sir Bernard Katz
    1972 – Gerald Maurice Edelman
    1975 – Howard Martin Temin
    1976 – Baruch S. Blumberg
    1977 – Roselyn Sussman Yalow
    1978 – Daniel Nathans
    1980 – Baruj Benacerraf
    1984 – Cesar Milstein
    1985 – Michael Stuart Brown
    1985 – Joseph L. Goldstein
    1986 – Stanley Cohen [& Rita Levi-Montalcini]
    1988 – Gertrude Elion
    1989 – Harold Varmus
    1991 – Erwin Neher
    1991 – Bert Sakmann
    1993 – Richard J. Roberts
    1993 – Phillip Sharp
    1994 – Alfred Gilman
    1995 – Edward Lewis
    1996 – Lu RoseIacovino
    TOTAL: 129!
    The Jews are NOT promoting the brain-washing of children in military training camps, teaching them how to blow themselves up and cause maximum deaths of Jews and other non-Muslims. The Jews don’t hijack planes, nor kill athletes at the Olympics, or blow themselves up in German restaurants. There is NOT one single Jew who has destroyed a church. There is NOT a single Jew who protests by killing people.
    The Jews don’t traffic slaves, nor have leaders calling for Jihad and death to all the Infidels.
    Perhaps the world’s Muslims should consider investing more in standard education and less in blaming the Jews for all their problems.
    Muslims must ask what they can do for humankind before they demand that humankind respects them.
    Regardless of your feelings about the crisis between Israel and the Palestinians and Arab neighbors, even if you believe there is more culpability on Israel’s part, the following two sentences really say it all:
    “If the Arabs put down their weapons today, there would be no more violence. If the Jews put down their weapons today, there would be no more Israel.” Benjamin Netanyahu
    General Eisenhower Warned Us.
    It is a matter of history that when the Supreme Commander of the Allied Forces, General Dwight Eisenhower, found the victims of the death camps, he ordered all possible photographs to be taken, and for the German people from surrounding villages to be ushered through the camps and even made to bury the dead.
    He did this because he said in words to this effect:
    “Get it all on record now – get the films – get the witnesses – because somewhere down the road of history some bastard will get up and say that this never happened.”
    Recently the UK debated whether to remove ‘The Holocaust’ from its school curriculum because it ‘offends’ the Muslim population, which claims it never, occurred. It is not removed as yet. However, this is a frightening portent of the fear that is gripping the world and how easily each country is giving into it.
    It is now more than 60 years after the Second World War in Europe ended.
    This e-mail is being sent as a memorial chain, in memory of the, 6 million Jews, 20 million Russians, 10 million Christians, and 1,900 Catholic priests who were murdered, raped, burned, starved, beaten, experimented on and humiliated while the German people looked the other way.
    Now more than ever, with Iran, among others, claiming the Holocaust to be a myth, it is imperative to make sure the world never forgets.
    This e-mail is intended to reach 400 million people. Be a link in the memorial chain and help distribute this around the world.
    How many years will it be before the attack on the World Trade Center ‘NEVER HAPPENED,’ because it offends some Muslim in the United States?
    Do not just delete this message. It will take only a minute to pass this along.
    All I have seen teaches me to trust the Creator for all I have not seen. -Ralph W. Emerson

  • http://www.ocimweb.com/ Berita Terkini

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