Friends til the End
Born from Kelsey Grammer's character on Cheers, Dr. Frasier Crane's marriage to the gothic Lilith dissolves with the rest of his life in Bostom, so he moves to Seattle to start over - as a host of a call-in radio talk show.
We were exposed to the lives - and antics - of the Frasier men over the course of 11 seasons, and with the exception of Kirstie Alley, all surviving main regular cast members of Cheers made guest appearances on Frasier.
Fun Facts: Lisa Kudrow was originally cast as Roz, Frasier's radio show producer, but due to lack of chemistry in rehearsals, the part was re-cast to Peri Gilpin. Only one episode of Frasier was ever filmed in Seattle, with the remainder filmed in Los Angeles.