Friends til the End
A series with political undercurrents, Family Ties featured liberal ex-hippie parents facing the cultural transition into the 1980's with the younger generation embracing traditional conservatism of the Reagan era.
Throughout 7 seasons, we see the evolving relationships of the Keaton family, with studious Alex and materialistic Mallory, while Jennifer just wants to be a kid.
Fun Fact: Michael J. Fox landed the role of Alex P. Keaton after Matthew Broderick turned it down.