This one is a bit awkward, as Scrubs regrettably aired one more season as a spin-off before closing the hospital doors, before doing so it put out one of the best series finales in recent memory.  It featured an appropriately heartwarming ending to the relationship between JD and Dr. Cox, who to that point had rarely opened up his heart about anything.  The finale even managed to bring back minor characters going all the way back to season 1, and JD walking down that hall of memories was both hilarious and emotional.  Hooch IS crazy!!